Association between statin use & risk of diffuse large B-cell lymphoma: A systematic review & meta-analysis
Issued Date
2023-06-01
Resource Type
ISSN
09715916
Scopus ID
2-s2.0-85165568095
Journal Title
Indian Journal of Medical Research
Volume
157
Issue
6
Start Page
543
End Page
548
Rights Holder(s)
SCOPUS
Bibliographic Citation
Indian Journal of Medical Research Vol.157 No.6 (2023) , 543-548
Suggested Citation
Ponvilawan B., Charoenngam N., Ungprasert P. Association between statin use & risk of diffuse large B-cell lymphoma: A systematic review & meta-analysis. Indian Journal of Medical Research Vol.157 No.6 (2023) , 543-548. 548. doi:10.4103/ijmr.IJMR_2668_19 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/88179
Title
Association between statin use & risk of diffuse large B-cell lymphoma: A systematic review & meta-analysis
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Background & objectives: Statin use has been shown to be associated with a decreased risk of several types of cancer, however, the data on diffuse large B-cell lymphoma (DLBCL) are still inconclusive. This study aimed to systematically summarize all available data on this association and conduct a meta-analysis on the same. Methods: A systematic review was performed using EMBASE and MEDLINE databases from inception upto October 2019 with a search strategy that included terms such as 'statin' and 'DLBCL'. Eligible studies included either case-control or cohort studies that reported the association between statin use and the risk of DLBCL. Relative risk, odds ratio (OR), hazard: risk ratio or standardized incidence ratio of this association and standard error were extracted and combined for calculating the pooled effect estimate using random-effects, generic inverse variance method. Results: A total of 1139 articles were screened. Of these six studies satisfied the inclusion criteria and were included for the meta-analysis. Statin use was associated with a significantly reduced risk of DLBCL with the pooled OR of 0.70 (95% confidence interval, 0.56-0.88; I 2 =70%). The funnel plot (fairly symmetric) was not suggestive of the presence of a publication bias. Interpretation & conclusions: The present systematic review and meta-analysis found that statin use is associated with a 30 per cent reduced odds of DLBCL. However, the pooled analysis utilized data from observational studies so causation cannot be concluded upon. Hence, it suggested that randomized-controlled studies are still needed to confirm this potential benefit.