Octane in exhaled breath to diagnose acute respiratory distress syndrome in invasively ventilated intensive care unit patients
Issued Date
2023-09-01
Resource Type
eISSN
23120541
Scopus ID
2-s2.0-85185258168
Journal Title
ERJ Open Research
Volume
9
Issue
5
Rights Holder(s)
SCOPUS
Bibliographic Citation
ERJ Open Research Vol.9 No.5 (2023)
Suggested Citation
Hagens L.A., Heijnen N.F.L., Smit M.R., Verschueren A.R.M., Nijsen T.M.E., Geven I., Presură C.N., Rietman R., Fenn D.W., Brinkman P., Schultz M.J., Bergmans D.C.J.J., Schnabel R.M., Bos L.D.J. Octane in exhaled breath to diagnose acute respiratory distress syndrome in invasively ventilated intensive care unit patients. ERJ Open Research Vol.9 No.5 (2023). doi:10.1183/23120541.00214-2023 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97344
Title
Octane in exhaled breath to diagnose acute respiratory distress syndrome in invasively ventilated intensive care unit patients
Corresponding Author(s)
Other Contributor(s)
Abstract
Background The concentration of exhaled octane has been postulated as a reliable biomarker for acute respiratory distress syndrome (ARDS) using metabolomics analysis with gas chromatography and mass spectrometry (GC-MS). A point-of-care (POC) breath test was developed in recent years to accurately measure octane at the bedside. The aim of the present study was to validate the diagnostic accuracy of exhaled octane for ARDS using a POC breath test in invasively ventilated intensive care unit (ICU) patients. Methods This was an observational cohort study of consecutive patients receiving invasive ventilation for at least 24 h, recruited in two university ICUs. GC-MS and POC breath tests were used to quantify the exhaled octane concentration. ARDS was assessed by three experts following the Berlin definition and used as the reference standard. The area under the receiver operating characteristic curve (AUC) was used to assess diagnostic accuracy. Results 519 patients were included and 190 (37%) fulfilled the criteria for ARDS. The median (interquartile range) concentration of octane using the POC breath test was not significantly different between patients with ARDS (0.14 (0.05–0.37) ppb) and without ARDS (0.11 (0.06–0.26) ppb; p=0.64). The AUC for ARDS based on the octane concentration in exhaled breath using the POC breath test was 0.52 (95% CI 0.46–0.57). Analysis of exhaled octane with GC-MS showed similar results. Conclusions Octane in exhaled breath has insufficient diagnostic accuracy for ARDS. This disqualifies the use of octane as a biomarker in the diagnosis of ARDS and challenges most of the research performed up to now in the field of exhaled breath metabolomics.