Enzymatic Synthesis of Functional PEGylated Adipate Copolymers
2
Issued Date
2025-01-01
Resource Type
eISSN
21926506
Scopus ID
2-s2.0-86000553295
Journal Title
ChemPlusChem
Rights Holder(s)
SCOPUS
Bibliographic Citation
ChemPlusChem (2025)
Suggested Citation
Axioti E., Dixon E.G., Jepras T., Tin He F., Hartman P.J.V., Hopkins B., Di Bari V., Suksiriworapong J., Cuzzucoli Crucitti V., Galantini L., Francolini I., Cavanagh R.J., Taresco V. Enzymatic Synthesis of Functional PEGylated Adipate Copolymers. ChemPlusChem (2025). doi:10.1002/cplu.202400668 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/106804
Title
Enzymatic Synthesis of Functional PEGylated Adipate Copolymers
Corresponding Author(s)
Other Contributor(s)
Abstract
Many new active pharmaceutical ingredients (APIs) demonstrate high hydrophobicity and low water-solubility issues. In this regard, polymeric nanoparticles (NPs) have been extensively used as drug delivery carriers for the encapsulation of such APIs. One commonly used polymer is polyethylene glycol (PEG), owing to its biocompatibility, high water solubility, and capacity to prolong the drug residence time. However, concerns have arisen regarding PEG's immunogenicity and limited biodegradability. In addition, inherent limitations, including limited chemical handles can restrict PEG's effectiveness in physiological conditions. For this reason, in the present study, we combine the advantages offered by PEG with the use of an enzymatic synthetic route to produce novel PEGylated polyesters. Furthermore, it has been proven that incorporation of hydrophobic diols into the PEGylated backbone influences NPs formation, stability, and drug encapsulation, despite high chemical similarity. As a preliminary result, samples containing PEG and 1,6-hexanediol in a 50 : 50 ratio (PEGA-Hex 50 %) and PEG and 2-hydroxyethyl disulfide in a 50 : 50 ratio (PEGA-SS 50 %) have proved to be the most promising candidates in this small library analysed. Both samples exhibited sufficient NPs stability, biocompatibility, and superior encapsulation efficiency compared to the other variants.