Assessment of changes in blood volume during lower body negative pressure-induced hypovolemia using bioelectrical impedance analysis
Issued Date
2023-01-01
Resource Type
ISSN
13871307
eISSN
15732614
Scopus ID
2-s2.0-85176798467
Journal Title
Journal of Clinical Monitoring and Computing
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Monitoring and Computing (2023)
Suggested Citation
Anakmeteeprugsa S., Gonzalez-Fiol A., Vychodil R., Shelley K., Alian A. Assessment of changes in blood volume during lower body negative pressure-induced hypovolemia using bioelectrical impedance analysis. Journal of Clinical Monitoring and Computing (2023). doi:10.1007/s10877-023-01098-y Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91207
Title
Assessment of changes in blood volume during lower body negative pressure-induced hypovolemia using bioelectrical impedance analysis
Author's Affiliation
Other Contributor(s)
Abstract
Background: Lower body negative Pressure (LBNP)-induced hypovolemia is simulating acute hemorrhage by sequestrating blood into lower extremities. Bioelectrical Impedance Analysis (BIA) is based on the electrical properties of biological tissues, as electrical current flows along highly conductive body tissues (such as blood). Changes in blood volume will lead to changes in bioimpedance. This study aims to study changes in upper (UL) and lower (LL) extremities bioimpedance during LBNP-induced hypovolemia. Methods: This was a prospective observational study of healthy volunteers who underwent gradual LBNP protocol which consisted of 3-minute intervals: at baseline, -15, -30, -45, -60 mmHg, then recovery phases at -30 mmHg and baseline. The UL&LL extremities bioimpedance were measured and recorded at each phase of LBNP and the percentage changes of bioimpedance from baseline were calculated and compared using student’s t-test. A P-value of < 0.05 was considered significant. Correlation between relative changes in UL&LL bioimpedance and estimated blood loss (EBL) from LBNP was calculated using Pearson correlation. Results: 26 healthy volunteers were enrolled. As LBNP-induced hypovolemia progressed, there were a significant increase in UL bioimpedance and a significant decrease in LL bioimpedance. During recovery phases (where blood was shifted from the legs to the body), there were a significant increase in LL bioimpedance and a reduction in UL bioimpedance. There were significant correlations between estimated blood loss from LBNP model with UL (R = 0.97) and LL bioimpedance (R = − 0.97). Conclusion: During LBNP-induced hypovolemia, there were reciprocal changes in UL&LL bioimpedance. These changes reflected hemodynamic compensatory mechanisms to hypovolemia.