Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium
Issued Date
2022-06-01
Resource Type
ISSN
08159319
eISSN
14401746
Scopus ID
2-s2.0-85132049824
Pubmed ID
35178742
Journal Title
Journal of Gastroenterology and Hepatology (Australia)
Volume
37
Issue
6
Start Page
1004
End Page
1015
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Gastroenterology and Hepatology (Australia) Vol.37 No.6 (2022) , 1004-1015
Suggested Citation
Banerjee R., Pal P., Hilmi I., Ghoshal U.C., Desai D.C., Rahman M.M., Dutta U., Mohiuddin S.A., Al Mohannadi M., Philip M., Ramesh G.N., Niriella M.A., De Silva A.P., de Silva H.J., Pisespongsa P., Limsrivilai J., Aniwan S., Nawarathne M., Fernandopulle N., Aye T.T., Ni N., Al Awadhi S., Joshi N., Ngoc P.T.V., Kieu T.V., Nguyen A.D., Abdullah M., Ali E., Zeid A., Sollano J.D., Saberi B., Omar M., Mohsin M.N., Aftab H., Wai T.M., Shastri Y.M., Chaudhuri S., Ahmed F., Bhatia S.J., Travis S.P.L. Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium. Journal of Gastroenterology and Hepatology (Australia) Vol.37 No.6 (2022) , 1004-1015. 1015. doi:10.1111/jgh.15801 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87294
Title
Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium
Author(s)
Banerjee R.
Pal P.
Hilmi I.
Ghoshal U.C.
Desai D.C.
Rahman M.M.
Dutta U.
Mohiuddin S.A.
Al Mohannadi M.
Philip M.
Ramesh G.N.
Niriella M.A.
De Silva A.P.
de Silva H.J.
Pisespongsa P.
Limsrivilai J.
Aniwan S.
Nawarathne M.
Fernandopulle N.
Aye T.T.
Ni N.
Al Awadhi S.
Joshi N.
Ngoc P.T.V.
Kieu T.V.
Nguyen A.D.
Abdullah M.
Ali E.
Zeid A.
Sollano J.D.
Saberi B.
Omar M.
Mohsin M.N.
Aftab H.
Wai T.M.
Shastri Y.M.
Chaudhuri S.
Ahmed F.
Bhatia S.J.
Travis S.P.L.
Pal P.
Hilmi I.
Ghoshal U.C.
Desai D.C.
Rahman M.M.
Dutta U.
Mohiuddin S.A.
Al Mohannadi M.
Philip M.
Ramesh G.N.
Niriella M.A.
De Silva A.P.
de Silva H.J.
Pisespongsa P.
Limsrivilai J.
Aniwan S.
Nawarathne M.
Fernandopulle N.
Aye T.T.
Ni N.
Al Awadhi S.
Joshi N.
Ngoc P.T.V.
Kieu T.V.
Nguyen A.D.
Abdullah M.
Ali E.
Zeid A.
Sollano J.D.
Saberi B.
Omar M.
Mohsin M.N.
Aftab H.
Wai T.M.
Shastri Y.M.
Chaudhuri S.
Ahmed F.
Bhatia S.J.
Travis S.P.L.
Author's Affiliation
Siriraj Hospital
AMRI Hospitals
Yangon General Hospital
Hamad General Hospital
University of Santo Tomas, Manila
University of Kelaniya
National Hospital of Sri Lanka
Rashid Hospital
NMC Specialty Hospital
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow
P.D. Hinduja National Hospital and Medical Research Centre
Dhaka Medical College and Hospital
King Chulalongkorn Memorial Hospital
Faculty of Medicine
Bumrungrad International Hospital
Asian Institute of Gastroenterology India
University of Malaya Medical Centre
Chittagong Medical College
John Radcliffe Hospital
Postgraduate Institute of Medical Education & Research, Chandigarh
Aster Hospital
New Mowasat Hospital
Amiri Medical Complex
Sir H.N. Reliance Foundation Hospital
Nidan Hospital
Bach Mai General Hospital
Mandalay General Hospital
University of Medicine 2
Lisie Hospital
AMRI Hospitals
Yangon General Hospital
Hamad General Hospital
University of Santo Tomas, Manila
University of Kelaniya
National Hospital of Sri Lanka
Rashid Hospital
NMC Specialty Hospital
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow
P.D. Hinduja National Hospital and Medical Research Centre
Dhaka Medical College and Hospital
King Chulalongkorn Memorial Hospital
Faculty of Medicine
Bumrungrad International Hospital
Asian Institute of Gastroenterology India
University of Malaya Medical Centre
Chittagong Medical College
John Radcliffe Hospital
Postgraduate Institute of Medical Education & Research, Chandigarh
Aster Hospital
New Mowasat Hospital
Amiri Medical Complex
Sir H.N. Reliance Foundation Hospital
Nidan Hospital
Bach Mai General Hospital
Mandalay General Hospital
University of Medicine 2
Lisie Hospital
Other Contributor(s)
Abstract
Background and Aim: Inflammatory bowel disease (IBD) is emerging in the newly industrialized countries of South Asia, South-East Asia, and the Middle East, yet epidemiological data are scarce. Methods: We performed a cross-sectional study of IBD demographics, disease phenotype, and treatment across 38 centers in 15 countries of South Asia, South-East Asia, and Middle East. Intergroup comparisons included gross national income (GNI) per capita. Results: Among 10 400 patients, ulcerative colitis (UC) was twice as common as Crohn's disease (CD), with a male predominance (UC 6678, CD 3495, IBD unclassified 227, and 58% male). Peak age of onset was in the third decade, with a low proportion of elderly-onset IBD (5% age > 60). Familial IBD was rare (5%). The extent of UC was predominantly distal (proctitis/left sided 67%), with most being treated with mesalamine (94%), steroids (54%), or immunomodulators (31%). Ileocolic CD (43%) was the commonest, with low rates of perianal disease (8%) and only 6% smokers. Diagnostic delay for CD was common (median 12 months; interquartile range 5–30). Treatment of CD included mesalamine, steroids, and immunomodulators (61%, 51%, and 56%, respectively), but a fifth received empirical antitubercular therapy. Treatment with biologics was uncommon (4% UC and 13% CD), which increased in countries with higher GNI per capita. Surgery rates were 0.1 (UC) and 2 (CD) per 100 patients per year. Conclusions: The IBD-ENC cohort provides insight into IBD in South-East Asia and the Middle East, but is not yet population based. UC is twice as common as CD, familial disease is uncommon, and rates of surgery are low. Biologic use correlates with per capita GNI.