Epigenetic regulation of epithelial–mesenchymal transition during cancer development
Issued Date
2023-01-01
Resource Type
ISSN
19376448
Scopus ID
2-s2.0-85162857383
Journal Title
International Review of Cell and Molecular Biology
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Review of Cell and Molecular Biology (2023)
Suggested Citation
Yoodee S., Thongboonkerd V. Epigenetic regulation of epithelial–mesenchymal transition during cancer development. International Review of Cell and Molecular Biology (2023). doi:10.1016/bs.ircmb.2023.05.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87755
Title
Epigenetic regulation of epithelial–mesenchymal transition during cancer development
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Epithelial–mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicating their involvement in cancer development. Mechanically, epigenetic modifications of histone, DNA, mRNA and non-coding RNA stably change the EMT-related gene expression at transcription and translation levels. Herein, we summarize current knowledge on epigenetic regulatory mechanisms observed in EMT process relate to cancer development in humans. The better understanding of epigenetic regulation of EMT during cancer development may lead to improvement of drug design and preventive strategies in cancer therapy.