Monkeypox: Immune response, vaccination and preventive efforts
Issued Date
2022-01-01
Resource Type
eISSN
28072618
Scopus ID
2-s2.0-85143122544
Journal Title
Narra J
Volume
2
Issue
3
Rights Holder(s)
SCOPUS
Bibliographic Citation
Narra J Vol.2 No.3 (2022)
Suggested Citation
Ophinni Y. Monkeypox: Immune response, vaccination and preventive efforts. Narra J Vol.2 No.3 (2022). doi:10.52225/narra.v2i3.90 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87401
Title
Monkeypox: Immune response, vaccination and preventive efforts
Author(s)
Author's Affiliation
Catholic University of Central Africa
Badan Riset dan Inovasi Nasional
Maldives National University
College of Medicine Alfaisal University
Parc Sanitari Sant Joan de Déu
School of Management and Medical Informatics
School of Medicine
Faculty of Tropical Medicine, Mahidol University
University of Puthisastra
Babcock University
Universitas Warmadewa
Institutionen för Translationell Medicin
WPI Immunology Frontier Research Center, Osaka University
Tribhuvan University Teaching Hospital
Jimma University
National Institute of Health Pakistan
Jordan University Hospital
Ministry of Health Saudi Arabia
Al-Quds University
Waikato Hospital
UC Davis School of Medicine
Massachusetts Institute of Technology
Bumrungrad International Hospital
Faculty of Medicine - Ain Shams University
MU College of Veterinary Medicine
University of Brighton
Johns Hopkins Bloomberg School of Public Health
Faculty of Medicine, Chulalongkorn University
Medical Research Foundation of Trinidad and Tobago
Yemen Field Epidemiology Training Program
Baku Medical Plaza
Städtisches Klinikum Dresden
Eastern Mediterranean Public Health Network
National Institute of Industrial Property
Badan Riset dan Inovasi Nasional
Maldives National University
College of Medicine Alfaisal University
Parc Sanitari Sant Joan de Déu
School of Management and Medical Informatics
School of Medicine
Faculty of Tropical Medicine, Mahidol University
University of Puthisastra
Babcock University
Universitas Warmadewa
Institutionen för Translationell Medicin
WPI Immunology Frontier Research Center, Osaka University
Tribhuvan University Teaching Hospital
Jimma University
National Institute of Health Pakistan
Jordan University Hospital
Ministry of Health Saudi Arabia
Al-Quds University
Waikato Hospital
UC Davis School of Medicine
Massachusetts Institute of Technology
Bumrungrad International Hospital
Faculty of Medicine - Ain Shams University
MU College of Veterinary Medicine
University of Brighton
Johns Hopkins Bloomberg School of Public Health
Faculty of Medicine, Chulalongkorn University
Medical Research Foundation of Trinidad and Tobago
Yemen Field Epidemiology Training Program
Baku Medical Plaza
Städtisches Klinikum Dresden
Eastern Mediterranean Public Health Network
National Institute of Industrial Property
Other Contributor(s)
Abstract
Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a self-limited disease, patients can suffer from extremely painful skin lesions and complications can occur with reported mortalities. The antigenic similarity between the smallpox virus (variola virus) and monkeypox virus can be utilized to prevent monkeypox using smallpox vaccines; treatment is also based on antivirals initially designed to treat smallpox. However, further studies are needed to fully decipher the immune response to monkeypox virus and the immune evasion mechanisms. In this review we provide an up-to-date discussion of the current state of knowledge regarding monkeypox virus with a special focus on innate immune response, immune evasion mechanisms and vaccination against the virus.