Diagnostic Performance of 10 Mathematical Formulae for Identifying Blood Donors with Thalassemia Trait
Issued Date
2023-11-02
Resource Type
eISSN
19437730
Scopus ID
2-s2.0-85176494831
Pubmed ID
36932722
Journal Title
Laboratory medicine
Volume
54
Issue
6
Start Page
593
End Page
597
Rights Holder(s)
SCOPUS
Bibliographic Citation
Laboratory medicine Vol.54 No.6 (2023) , 593-597
Suggested Citation
Noulsri E., Lerdwana S., Palasuwan D., Palasuwan A. Diagnostic Performance of 10 Mathematical Formulae for Identifying Blood Donors with Thalassemia Trait. Laboratory medicine Vol.54 No.6 (2023) , 593-597. 597. doi:10.1093/labmed/lmad011 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91190
Title
Diagnostic Performance of 10 Mathematical Formulae for Identifying Blood Donors with Thalassemia Trait
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
OBJECTIVE: To compare the diagnostic performance of 10 mathematical formulae for identifying thalassemia trait in blood donors. METHODS: Compete blood counts were conducted on peripheral blood specimens using the UniCel DxH 800 hematology analyzer. Receiver operating characteristic curves were used to evaluate the diagnostic performance of each mathematical formula. RESULTS: In the 66 donors with thalassemia and 288 subjects with no thalassemia analyzed, donors with thalassemia trait had lower values for mean corpuscular volume and mean corpuscular hemoglobin than subjects without thalassemia donors (77 fL vs 86 fL [P < .001]; 25 pg vs 28 pg [P < .001]). The formula developed by Shine and Lal in 1977 showed the highest area under the curve value, namely, 0.9. At the cutoff value of <1812, this formula had maximum specificity of 82.35% and sensitivity of 89.58%. CONCLUSIONS: Our data indicate that the Shine and Lal formula has remarkable diagnostic performance in identifying donors with underlying thalassemia trait.