Application of the international criteria for optic neuritis in the Acute Optic Neuritis Network
Issued Date
2024-01-01
Resource Type
eISSN
23289503
Scopus ID
2-s2.0-85200408420
Journal Title
Annals of Clinical and Translational Neurology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Annals of Clinical and Translational Neurology (2024)
Suggested Citation
Klyscz P., Asseyer S., Alonso R., Bereuter C., Bialer O., Bick A., Carta S., Chen J.J., Cohen L., Cohen-Tayar Y., Contentti E.C., Dale R.C., Flanagan E.P., Gernert J.A., Haas J., Havla J., Heesen C., Hellmann M., Levin N., Lopez P., Lotan I., Luis M.B., Mariotto S., Mayer C., Vergara A.J.M., Ocampo C., Ochoa S., Oertel F.C., Olszewska M., Uribe J.L.P., Sastre-Garriga J., Scocco D., Ramanathan S., Rattanathamsakul N., Shi F.D., Shifa J., Simantov I., Siritho S., Tiosano A., Tisavipat N., Torres I., Dembinsky A.V., Vidal-Jordana A., Wilf-Yarkoni A., Wu T., Zamir S., Zarco L.A., Zimmermann H.G., Petzold A., Paul F., Stiebel-Kalish H. Application of the international criteria for optic neuritis in the Acute Optic Neuritis Network. Annals of Clinical and Translational Neurology (2024). doi:10.1002/acn3.52166 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100414
Title
Application of the international criteria for optic neuritis in the Acute Optic Neuritis Network
Author(s)
Klyscz P.
Asseyer S.
Alonso R.
Bereuter C.
Bialer O.
Bick A.
Carta S.
Chen J.J.
Cohen L.
Cohen-Tayar Y.
Contentti E.C.
Dale R.C.
Flanagan E.P.
Gernert J.A.
Haas J.
Havla J.
Heesen C.
Hellmann M.
Levin N.
Lopez P.
Lotan I.
Luis M.B.
Mariotto S.
Mayer C.
Vergara A.J.M.
Ocampo C.
Ochoa S.
Oertel F.C.
Olszewska M.
Uribe J.L.P.
Sastre-Garriga J.
Scocco D.
Ramanathan S.
Rattanathamsakul N.
Shi F.D.
Shifa J.
Simantov I.
Siritho S.
Tiosano A.
Tisavipat N.
Torres I.
Dembinsky A.V.
Vidal-Jordana A.
Wilf-Yarkoni A.
Wu T.
Zamir S.
Zarco L.A.
Zimmermann H.G.
Petzold A.
Paul F.
Stiebel-Kalish H.
Asseyer S.
Alonso R.
Bereuter C.
Bialer O.
Bick A.
Carta S.
Chen J.J.
Cohen L.
Cohen-Tayar Y.
Contentti E.C.
Dale R.C.
Flanagan E.P.
Gernert J.A.
Haas J.
Havla J.
Heesen C.
Hellmann M.
Levin N.
Lopez P.
Lotan I.
Luis M.B.
Mariotto S.
Mayer C.
Vergara A.J.M.
Ocampo C.
Ochoa S.
Oertel F.C.
Olszewska M.
Uribe J.L.P.
Sastre-Garriga J.
Scocco D.
Ramanathan S.
Rattanathamsakul N.
Shi F.D.
Shifa J.
Simantov I.
Siritho S.
Tiosano A.
Tisavipat N.
Torres I.
Dembinsky A.V.
Vidal-Jordana A.
Wilf-Yarkoni A.
Wu T.
Zamir S.
Zarco L.A.
Zimmermann H.G.
Petzold A.
Paul F.
Stiebel-Kalish H.
Author's Affiliation
Siriraj Hospital
Hospital Universitario San Ignacio
Università degli Studi di Verona
Concord Repatriation General Hospital
The Children's Hospital at Westmead
Charité – Universitätsmedizin Berlin
The University of Sydney
Max Delbruck Center for Molecular Medicine
University College London
Rabin Medical Center Israel
University of Botswana
Bumrungrad International Hospital
Moorfields Eye Hospital NHS Foundation Trust
University of Florida
Hospital Universitari Vall d'Hebron
Tianjin Medical University
Hebrew University of Jerusalem
Hospital Aleman
Tel Aviv University
Mayo Clinic
Universitätsklinikum Hamburg-Eppendorf
Harvard Medical School
Hospital J.M. Ramos Mejia, Buenos Aires
Klinikum der Universität München
Neuro-ophthalmology Expert Center
Einstein Center Digital Future
Hospital Universitario San Ignacio
Università degli Studi di Verona
Concord Repatriation General Hospital
The Children's Hospital at Westmead
Charité – Universitätsmedizin Berlin
The University of Sydney
Max Delbruck Center for Molecular Medicine
University College London
Rabin Medical Center Israel
University of Botswana
Bumrungrad International Hospital
Moorfields Eye Hospital NHS Foundation Trust
University of Florida
Hospital Universitari Vall d'Hebron
Tianjin Medical University
Hebrew University of Jerusalem
Hospital Aleman
Tel Aviv University
Mayo Clinic
Universitätsklinikum Hamburg-Eppendorf
Harvard Medical School
Hospital J.M. Ramos Mejia, Buenos Aires
Klinikum der Universität München
Neuro-ophthalmology Expert Center
Einstein Center Digital Future
Corresponding Author(s)
Other Contributor(s)
Abstract
Objective: The first international consensus criteria for optic neuritis (ICON) were published in 2022. We applied these criteria to a prospective, global observational study of acute optic neuritis (ON). Methods: We included 160 patients with a first-ever acute ON suggestive of a demyelinating CNS disease from the Acute Optic Neuritis Network (ACON). We applied the 2022 ICON to all participants and subsequently adjusted the ICON by replacing a missing relative afferent pupillary defect (RAPD) or dyschromatopsia if magnetic resonance imaging pathology of the optical nerve plus optical coherence tomography abnormalities or certain biomarkers are present. Results: According to the 2022 ICON, 80 (50%) patients were classified as definite ON, 12 (7%) patients were classified as possible ON, and 68 (43%) as not ON (NON). The main reasons for classification as NON were absent RAPD (52 patients, 76%) or dyschromatopsia (49 patients, 72%). Distribution of underlying ON etiologies was as follows: 78 (49%) patients had a single isolated ON, 41 (26%) patients were diagnosed with multiple sclerosis, 25 (16%) patients with myelin oligodendrocyte glycoprotein antibody-associated disease, and 15 (9%) with neuromyelitis optica spectrum disorder. The application of the adjusted ON criteria yielded a higher proportion of patients classified as ON (126 patients, 79%). Interpretation: According to the 2022 ICON, almost half of the included patients in ACON did not fulfill the requirements for classification of definite or possible ON, particularly due to missing RAPD and dyschromatopsia. Thorough RAPD examination and formal color vision testing are critical to the application of the 2022 ICON.