Breakthrough SARS-CoV-2 infection in fully vaccinated patients with systemic lupus erythematosus: results from the COVID-19 Vaccination in Autoimmune Disease (COVAD) study
Issued Date
2024-01-01
Resource Type
ISSN
01728172
eISSN
1437160X
Scopus ID
2-s2.0-85202492482
Journal Title
Rheumatology International
Rights Holder(s)
SCOPUS
Bibliographic Citation
Rheumatology International (2024)
Suggested Citation
Palazzo L., Lindblom J., Kihlgren Olsson E., Nikiphorou E., Wincup C., Saha S., Shaharir S.S., Katchamart W., Akarawatcharangura Goo P., Traboco L., Chen Y.M., Lilleker J.B., Nune A., Pauling J.D., Agarwal V., Dzifa D., Toro Gutiérrez C.E., Caballero-Uribe C.V., Chinoy H., Zimba O., Fonseca J.E., Pereira Silva J.A., Rojas Zuleta W.G., Shaharir S.S., Landon-Cardinal O., Hudson M., Srivastav N., Needham M., Limaye V., Langguth D., Nagy-Vincze M., Meyer A., Campagne J., Maurier F., Giannini M., Hoff L.S., Hmamouchi I., Gheita T.A., Aharonov O., Gromova M.A., Tomaras S., Knitza J., Kaneko Y., Kimura N., Sato S., Nakashima R., Yoshida A., Kuwana M., Gonzalez R.A., Gil-Vila A., Prieto-González S., Loarce-Martos J., García-De La Torre I., Serrano J.R., Tehozol E.A.Z., Wibowo S.A.K., Traboco L., Milchert M., Venerito V., Danielli M.G., De Angelis R., Orsolini G., Sainaghi P.P., Franceschini F., Quartuccio L., Sebastiani M., Fusaro E., Sebastiani G.D., Bocci E.B., Parisi S., Govoni M., Fabiola A., Sambataro G., Del Papa N., Cavagna L., Wincup C., Pauling J.D., Chatterjee T., Makol A., Kim M., Cansu D.Ü., Kardes S., Chandwar K., Pandey A.K.R., Shukla A., Bommakanti K.T., Asranna A., Shenoy P., Mathew A.J., Chowdhury A.C., Goswami R.P., Phatak S., Ajmani S., Patro P.S., Kavadichanda C.G., Gupta V., M M.M., Sharma A., Pilania R.K., Pandya S.C. Breakthrough SARS-CoV-2 infection in fully vaccinated patients with systemic lupus erythematosus: results from the COVID-19 Vaccination in Autoimmune Disease (COVAD) study. Rheumatology International (2024). doi:10.1007/s00296-024-05682-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100940
Title
Breakthrough SARS-CoV-2 infection in fully vaccinated patients with systemic lupus erythematosus: results from the COVID-19 Vaccination in Autoimmune Disease (COVAD) study
Author(s)
Palazzo L.
Lindblom J.
Kihlgren Olsson E.
Nikiphorou E.
Wincup C.
Saha S.
Shaharir S.S.
Katchamart W.
Akarawatcharangura Goo P.
Traboco L.
Chen Y.M.
Lilleker J.B.
Nune A.
Pauling J.D.
Agarwal V.
Dzifa D.
Toro Gutiérrez C.E.
Caballero-Uribe C.V.
Chinoy H.
Zimba O.
Fonseca J.E.
Pereira Silva J.A.
Rojas Zuleta W.G.
Shaharir S.S.
Landon-Cardinal O.
Hudson M.
Srivastav N.
Needham M.
Limaye V.
Langguth D.
Nagy-Vincze M.
Meyer A.
Campagne J.
Maurier F.
Giannini M.
Hoff L.S.
Hmamouchi I.
Gheita T.A.
Aharonov O.
Gromova M.A.
Tomaras S.
Knitza J.
Kaneko Y.
Kimura N.
Sato S.
Nakashima R.
Yoshida A.
Kuwana M.
Gonzalez R.A.
Gil-Vila A.
Prieto-González S.
Loarce-Martos J.
García-De La Torre I.
Serrano J.R.
Tehozol E.A.Z.
Wibowo S.A.K.
Traboco L.
Milchert M.
Venerito V.
Danielli M.G.
De Angelis R.
Orsolini G.
Sainaghi P.P.
Franceschini F.
Quartuccio L.
Sebastiani M.
Fusaro E.
Sebastiani G.D.
Bocci E.B.
Parisi S.
Govoni M.
Fabiola A.
Sambataro G.
Del Papa N.
Cavagna L.
Wincup C.
Pauling J.D.
Chatterjee T.
Makol A.
Kim M.
Cansu D.Ü.
Kardes S.
Chandwar K.
Pandey A.K.R.
Shukla A.
Bommakanti K.T.
Asranna A.
Shenoy P.
Mathew A.J.
Chowdhury A.C.
Goswami R.P.
Phatak S.
Ajmani S.
Patro P.S.
Kavadichanda C.G.
Gupta V.
M M.M.
Sharma A.
Pilania R.K.
Pandya S.C.
Lindblom J.
Kihlgren Olsson E.
Nikiphorou E.
Wincup C.
Saha S.
Shaharir S.S.
Katchamart W.
Akarawatcharangura Goo P.
Traboco L.
Chen Y.M.
Lilleker J.B.
Nune A.
Pauling J.D.
Agarwal V.
Dzifa D.
Toro Gutiérrez C.E.
Caballero-Uribe C.V.
Chinoy H.
Zimba O.
Fonseca J.E.
Pereira Silva J.A.
Rojas Zuleta W.G.
Shaharir S.S.
Landon-Cardinal O.
Hudson M.
Srivastav N.
Needham M.
Limaye V.
Langguth D.
Nagy-Vincze M.
Meyer A.
Campagne J.
Maurier F.
Giannini M.
Hoff L.S.
Hmamouchi I.
Gheita T.A.
Aharonov O.
Gromova M.A.
Tomaras S.
Knitza J.
Kaneko Y.
Kimura N.
Sato S.
Nakashima R.
Yoshida A.
Kuwana M.
Gonzalez R.A.
Gil-Vila A.
Prieto-González S.
Loarce-Martos J.
García-De La Torre I.
Serrano J.R.
Tehozol E.A.Z.
Wibowo S.A.K.
Traboco L.
Milchert M.
Venerito V.
Danielli M.G.
De Angelis R.
Orsolini G.
Sainaghi P.P.
Franceschini F.
Quartuccio L.
Sebastiani M.
Fusaro E.
Sebastiani G.D.
Bocci E.B.
Parisi S.
Govoni M.
Fabiola A.
Sambataro G.
Del Papa N.
Cavagna L.
Wincup C.
Pauling J.D.
Chatterjee T.
Makol A.
Kim M.
Cansu D.Ü.
Kardes S.
Chandwar K.
Pandey A.K.R.
Shukla A.
Bommakanti K.T.
Asranna A.
Shenoy P.
Mathew A.J.
Chowdhury A.C.
Goswami R.P.
Phatak S.
Ajmani S.
Patro P.S.
Kavadichanda C.G.
Gupta V.
M M.M.
Sharma A.
Pilania R.K.
Pandya S.C.
Author's Affiliation
Siriraj Hospital
UCL Division of Medicine
Faculty of Biology, Medicine and Health
Bristol Medical School
Southport and Ormskirk Hospital NHS Trust
Manchester University NHS Foundation Trust
Pontificia Universidad Javeriana, Cali
Universidad del Norte
North Bristol NHS Trust
University College London
Mymensingh Medical College
King's College Hospital
Karolinska Universitetssjukhuset
University of Ghana
King's College London
Salford Royal NHS Foundation Trust
Veterans General Hospital-Taichung Taiwan
Salford Royal Hospital
Faculty of Medicine, UKM
Mahatma Gandhi Mission Medical College
St. Luke's Medical Center Global City
Queen Savang Vadhana Memorial Hospital
UCL Division of Medicine
Faculty of Biology, Medicine and Health
Bristol Medical School
Southport and Ormskirk Hospital NHS Trust
Manchester University NHS Foundation Trust
Pontificia Universidad Javeriana, Cali
Universidad del Norte
North Bristol NHS Trust
University College London
Mymensingh Medical College
King's College Hospital
Karolinska Universitetssjukhuset
University of Ghana
King's College London
Salford Royal NHS Foundation Trust
Veterans General Hospital-Taichung Taiwan
Salford Royal Hospital
Faculty of Medicine, UKM
Mahatma Gandhi Mission Medical College
St. Luke's Medical Center Global City
Queen Savang Vadhana Memorial Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Objective: To determine the occurrence of breakthrough COVID-19 infections (BIs) in patients with systemic lupus erythematosus (SLE) compared with patients with other rheumatic autoimmune diseases (rAIDs), patients with non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HCs). Methods: The study was based on data from 7035 fully vaccinated respondents to the online COVAD questionnaire with SLE (N = 852), rAIDs (N = 3098), or nrAIDs (N = 414), and HCs (N = 2671). BI was defined as COVID-19 infection occurring in individuals vaccinated with ≥ 2 doses (or 1 dose of J&J) ≥ 14 days after vaccination and not after 6 months since the last vaccine dose. Data were analysed using linear and logistic regression models. Results: A total of 91/852 (10.7%) SLE patients reported at least one BI. The frequency of BIs in SLE patients was comparable to that among HCs (277/2671; p = 0.847) and patients with nrAID (39/414; p = 0.552) but higher than that among patients with other rAIDs (235/3098; p = 0.005). No demographic factors or treatments were associated with BIs in SLE patients (p ≥ 0.05 for all). Joint pain was more frequent in SLE patients than in HCs (odds ratio [OR]: 3.38; 95% confidence interval [CI]: 1.89–6.04; p < 0.001) or nrAID patients (OR: 2.44; 95% CI: 1.04–5.75; p = 0.041). Patient with SLE did not report a higher frequency of hospitalisation or need for advanced treatment for COVID-19 infection compared with disease controls and HCs, respectively. Conclusion: COVID-19 vaccination conferred similar protection against COVID-19 infection in terms of frequency and severity in patients with SLE to that reported by healthy individuals.
