D-Penicillamine-Induced Stevens–Johnson Syndrome in a Patient with Gold Cyanide Intoxication: A Case Report
Issued Date
2024-01-01
Resource Type
eISSN
11787015
Scopus ID
2-s2.0-85208613047
Journal Title
Clinical, Cosmetic and Investigational Dermatology
Volume
17
Start Page
2409
End Page
2415
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical, Cosmetic and Investigational Dermatology Vol.17 (2024) , 2409-2415
Suggested Citation
Anuntrangsee T., Chanprapaph K., Iamsumang W. D-Penicillamine-Induced Stevens–Johnson Syndrome in a Patient with Gold Cyanide Intoxication: A Case Report. Clinical, Cosmetic and Investigational Dermatology Vol.17 (2024) , 2409-2415. 2415. doi:10.2147/CCID.S489028 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102053
Title
D-Penicillamine-Induced Stevens–Johnson Syndrome in a Patient with Gold Cyanide Intoxication: A Case Report
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Author's Affiliation
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Abstract
D-penicillamine is used as the mainstay of chelation therapy for Wilson’s disease and for heavy metal intoxication. D-penicillamine itself has been noted to cause several systemic side effects as well as symptoms related to the skin. Common cutaneous side effects such as acute hypersensitivity reactions, elastic fiber abnormalities, and bullous diseases have been occasionally described. Herein, we report a case of a 23-year-old Thai female with gold intoxication who developed Stevens–Johnson syndrome (SJS) following the treatment of D-penicillamine. To our knowledge, D-penicillamine-induced SJS is exceptionally rare. To raise awareness of potentially fatal cutaneous adverse drug reaction triggered by D-penicillamine, published literature regarding SJS induced by this agent has also been reviewed. D-penicillamine should be regarded as a possible culprit in patients presenting with SJS following D-penicillamine administration and should be promptly discontinued.
