Cytokine and chemokine kinetics in natural human dengue infection as predictors of disease outcome
Issued Date
2025-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-105004343441
Journal Title
Scientific Reports
Volume
15
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.15 No.1 (2025)
Suggested Citation
Jiravejchakul N., Chan-in W., Thuncharoen W., Pakchotanon P., Duangchinda T., Thaloengsok S., Pitabut N., Manopwisedjaroen K., Yingtaweesak T., Suraamornkul S., Singhasivanon P., Sakuntabhai A., Sungnak W., Charoensawan V., Vacharathit V., Matangkasombut P. Cytokine and chemokine kinetics in natural human dengue infection as predictors of disease outcome. Scientific Reports Vol.15 No.1 (2025). doi:10.1038/s41598-025-99628-y Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/110074
Title
Cytokine and chemokine kinetics in natural human dengue infection as predictors of disease outcome
Author's Affiliation
Faculty of Science, Mahidol University
Siriraj Hospital
Faculty of Tropical Medicine, Mahidol University
Suranaree University of Technology
King Mongkut's Institute of Technology Ladkrabang
Vajira Hospital
Armed Forces Research Institute of Medical Sciences, Thailand
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
CNRS Centre National de la Recherche Scientifique
Institut Pasteur, Paris
Thasongyang Hospital
Siriraj Hospital
Faculty of Tropical Medicine, Mahidol University
Suranaree University of Technology
King Mongkut's Institute of Technology Ladkrabang
Vajira Hospital
Armed Forces Research Institute of Medical Sciences, Thailand
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
CNRS Centre National de la Recherche Scientifique
Institut Pasteur, Paris
Thasongyang Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Dengue is an important tropical disease with considerable global impact. Despite this, there remains an urgent need for reliable biomarkers to predict disease severity, as well as effective antiviral drugs and targeted treatments. In this study, we conducted a comprehensive profiling of 41 plasma mediators in patients with asymptomatic dengue (AD) and symptomatic dengue (SD), which includes mild dengue fever (DF) and severe dengue hemorrhagic fever (DHF). Our findings revealed that the levels of nearly all measured mediators were consistently lower in AD compared to SD patients, suggesting a potential protective cytokine response signature. Time-course cytokine analysis in SD shown significantly elevated levels of pro-inflammatory cytokines and chemokines associated with inflammation and viral clearance upon the acute phase, while various growth factors were elevated during the convalescence. Notably, we identified elevated IL-15 levels in DHF patients three days before fever subsidence, highlighting its potential as an early prognostic biomarker for severe disease outcomes. Furthermore, prolonged high levels of IL-8 and IP-10 in DHF during the critical period may contribute to dengue immunopathogenesis. This study advances the understanding of cytokine dynamics in the natural course of human dengue infection, providing valuable insights for the development of targeted treatments and prognostic biomarkers.