Benefits of Inactivated Vaccine and Viral Vector Vaccine Immunization on COVID-19 Infection in Kidney Transplant Recipients
Issued Date
2022-04-01
Resource Type
eISSN
2076393X
Scopus ID
2-s2.0-85128452061
Journal Title
Vaccines
Volume
10
Issue
4
Rights Holder(s)
SCOPUS
Bibliographic Citation
Vaccines Vol.10 No.4 (2022)
Suggested Citation
Sutharattanapong N., Thotsiri S., Kantachuvesiri S., Wiwattanathum P. Benefits of Inactivated Vaccine and Viral Vector Vaccine Immunization on COVID-19 Infection in Kidney Transplant Recipients. Vaccines Vol.10 No.4 (2022). doi:10.3390/vaccines10040572 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85001
Title
Benefits of Inactivated Vaccine and Viral Vector Vaccine Immunization on COVID-19 Infection in Kidney Transplant Recipients
Author's Affiliation
Other Contributor(s)
Abstract
The coronavirus virus disease 2019 (COVID-19) pandemic has impacted the global health-care system. In Thailand, the first and most available vaccines were inactivated and viral vector vaccines. We reported the impact of those vaccines in preventing severe disease and death in kidney transplant recipients. This retrospective study comprised 45 kidney transplant recipients with COVID-19 infection, classified by vaccination status. Outcomes of interest were death, pneumonia, and allograft dysfunction. There were 23 patients in vaccinated group and 22 patients in unvaccinated group. All baseline characteristics were similar except mean age was older in vaccinated group, 55 vs. 48 years. Total 11 patients (24%) died (13% vaccinated vs. 36% unvaccinated RR, 0.56; 95% CI, 0.29–0.83; p = 0.03). Multivariate analysis showed that vaccination significantly decrease mortality (odds ratio, 0.54; 95% CI, 0.10–0.94; p = 0.03). Pneumonia developed equally in both groups (70%). There was a trend toward less oxygen requirement as well as ventilator requirement in vaccinated group. The rate of allograft dysfunction was similar (47%). Inactivated and viral vector COVID-19 vaccines have beneficial effect on mortality reduction in kidney transplant recipients. Even partial vaccination can exert some protection against death. However, full vaccination should be encouraged to achieve better prevention.