A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update
151
Issued Date
2025-01-01
Resource Type
eISSN
26628465
Scopus ID
2-s2.0-105021238748
Journal Title
Nature Aging
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Aging (2025)
Suggested Citation
Chen L.K., Hsiao F.Y., Akishita M., Assantachai P., Lee W.J., Lim W.S., Muangpaisan W., Kim M., Merchant R.A., Peng L.N., Tan M.P., Won C.W., Yamada M., Woo J., Arai H. A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update. Nature Aging (2025). doi:10.1038/s43587-025-01004-y Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113118
Title
A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update
Author's Affiliation
National University of Singapore
Chinese University of Hong Kong
University of Tsukuba
Universiti Malaya
National Taiwan University Hospital
NUS Yong Loo Lin School of Medicine
Taipei Veterans General Hospital
National Taiwan University College of Medicine
National Yang Ming Chiao Tung University
Siriraj Hospital
KyungHee University College of Medicine
Lee Kong Chian School of Medicine
National Center for Geriatrics and Gerontology
Tokyo Metropolitan Institute for Geriatrics and Gerontology
Taipei Municipal Gan-Dau Hospital
Chinese University of Hong Kong
University of Tsukuba
Universiti Malaya
National Taiwan University Hospital
NUS Yong Loo Lin School of Medicine
Taipei Veterans General Hospital
National Taiwan University College of Medicine
National Yang Ming Chiao Tung University
Siriraj Hospital
KyungHee University College of Medicine
Lee Kong Chian School of Medicine
National Center for Geriatrics and Gerontology
Tokyo Metropolitan Institute for Geriatrics and Gerontology
Taipei Municipal Gan-Dau Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
The Asian Working Group for Sarcopenia (AWGS) presents an updated 2025 consensus reframing sarcopenia management through a life-course approach to muscle health promotion. While aligning with the Global Leadership Initiative in Sarcopenia (GLIS), this update provides healthcare providers with Asia-specific guidance. The consensus introduces three key refinements: first, expanding sarcopenia diagnosis to middle-aged adults (50‒64 years) with validated diagnostic thresholds; second, simplifying the diagnostic algorithm to require only concurrent low muscle mass and strength, with physical performance as an outcome measure; and third, introducing an enhanced muscle health framework recognizing skeletal muscle as vital for healthy longevity, emphasizing cross-talk with brain, bone, adipose tissue and immune systems. This framework leverages the World Health Organization’s Integrated Care for Older People (ICOPE) implementation for enhanced case-finding through natural overlap between muscle health and ICOPE’s intrinsic capacity domains. The consensus provides evidence-based recommendations for multimodal interventions that combine resistance exercise with nutritional supplementation, representing advancement toward proactive muscle health promotion and establishing a framework for reducing age-related decline in Asian populations.