A prospective cohort study on effects of mandibular setback with or without maxillary advancement for skeletal class III malocclusion on sleep-related respiratory parameters
Issued Date
2025-05-01
Resource Type
ISSN
15209512
eISSN
15221709
Scopus ID
2-s2.0-105004219590
Pubmed ID
40304815
Journal Title
Sleep and Breathing
Volume
29
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Sleep and Breathing Vol.29 No.2 (2025)
Suggested Citation
Patharakorn R., Saengfai N.N., Chaweewannakorn C., Boonpratham S., Satravaha Y., Peanchitlertkajorn S. A prospective cohort study on effects of mandibular setback with or without maxillary advancement for skeletal class III malocclusion on sleep-related respiratory parameters. Sleep and Breathing Vol.29 No.2 (2025). doi:10.1007/s11325-025-03347-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110116
Title
A prospective cohort study on effects of mandibular setback with or without maxillary advancement for skeletal class III malocclusion on sleep-related respiratory parameters
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Corresponding Author(s)
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Abstract
Purpose: This study aimed to investigate changes in sleep-related respiratory parameters before and after orthognathic surgery in patients with skeletal class III malocclusion. Methods: Adults with skeletal class III malocclusion and treated with isolated mandibular setback or bimaxillary surgery (maxillary advancement and mandibular setback) were recruited. Sleep-related respiratory parameters were obtained with type III sleep study. Epworth Sleepiness Scale (ESS) was also recorded. The pre- and post-operative (6 months) data were compared. Correlations between these changes and pre-operative characteristics were analyzed. Subjects were categorized into three groups based on changes in the respiratory event index (REI) and 3% oxygen desaturation index: Δ ≤ -2.5, -2.5 < Δ < 2.5, and Δ ≥ 2.5. Amounts of surgical movement and pre-surgical parameters were compared among the 3 groups. Results: Thirty patients with an average age of 25.4 ± 5.0 years were recruited. Eleven patients underwent isolated mandibular setbacks while nineteen received bimaxillary surgery. Pre- and post-operative sleep-related respiratory parameters were not significantly different in the total samples, and when analyzed separately according to surgical procedures. Pre-operative ESS were correlated with the changes in REI (p = 0.01), average blood oxygen levels (p = 0.01), and snoring percentage (p = 0.04). Additionally, this study found that patients with a significant decrease in REI (ΔREI ≤ -2.5) after surgery had significantly higher pre-operative REI (6.2 events/hour) compared to those with minor REI changes (2.6 events/hour). Conclusion: There was no significant change in sleep-related respiratory parameters following mandibular setbacks with or without maxillary advancement in this study. Trail registered: This study was retrospectively registered and approved on February 11, 2025, under registration number TCTR20250211002.