Rest and Stress Left Atrial Dysfunction in Patients with Atrial Fibrillation
Issued Date
2023-09-01
Resource Type
eISSN
20770383
Scopus ID
2-s2.0-85172875514
Journal Title
Journal of Clinical Medicine
Volume
12
Issue
18
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Medicine Vol.12 No.18 (2023)
Suggested Citation
Zagatina A., Rivadeneira Ruiz M., Ciampi Q., Wierzbowska-Drabik K., Kasprzak J., Kalinina E., Begidova I., Peteiro J., Arbucci R., Marconi S., Lowenstein J., Boshchenko A., Manganelli F., Čelutkienė J., Morrone D., Merli E., Re F., Borguezan-Daros C., Haberka M., Saad A.K., Djordjevic-Dikic A., Ratanasit N.C., Rigo F., Colonna P., Pretto J.L.d.C.e.S., Mori F., D’Alfonso M.G., Ostojic M., Stanetic B., Preradovic T.K., Costantino F., Barbieri A., Citro R., Pitino A., Pepi M., Carerj S., Pellikka P.A., Picano E. Rest and Stress Left Atrial Dysfunction in Patients with Atrial Fibrillation. Journal of Clinical Medicine Vol.12 No.18 (2023). doi:10.3390/jcm12185893 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90361
Title
Rest and Stress Left Atrial Dysfunction in Patients with Atrial Fibrillation
Author(s)
Zagatina A.
Rivadeneira Ruiz M.
Ciampi Q.
Wierzbowska-Drabik K.
Kasprzak J.
Kalinina E.
Begidova I.
Peteiro J.
Arbucci R.
Marconi S.
Lowenstein J.
Boshchenko A.
Manganelli F.
Čelutkienė J.
Morrone D.
Merli E.
Re F.
Borguezan-Daros C.
Haberka M.
Saad A.K.
Djordjevic-Dikic A.
Ratanasit N.C.
Rigo F.
Colonna P.
Pretto J.L.d.C.e.S.
Mori F.
D’Alfonso M.G.
Ostojic M.
Stanetic B.
Preradovic T.K.
Costantino F.
Barbieri A.
Citro R.
Pitino A.
Pepi M.
Carerj S.
Pellikka P.A.
Picano E.
Rivadeneira Ruiz M.
Ciampi Q.
Wierzbowska-Drabik K.
Kasprzak J.
Kalinina E.
Begidova I.
Peteiro J.
Arbucci R.
Marconi S.
Lowenstein J.
Boshchenko A.
Manganelli F.
Čelutkienė J.
Morrone D.
Merli E.
Re F.
Borguezan-Daros C.
Haberka M.
Saad A.K.
Djordjevic-Dikic A.
Ratanasit N.C.
Rigo F.
Colonna P.
Pretto J.L.d.C.e.S.
Mori F.
D’Alfonso M.G.
Ostojic M.
Stanetic B.
Preradovic T.K.
Costantino F.
Barbieri A.
Citro R.
Pitino A.
Pepi M.
Carerj S.
Pellikka P.A.
Picano E.
Author's Affiliation
Siriraj Hospital
Cardiology Research lnstitute, Tomsk National Research Medical Center, Russian Academy of Sciences
Medical University of Lodz, Bieganski Hospital
Ospedale San Carlo, Potenza
Ospedale per gli Infermi di Faenza
Azienda Ospedaliera S.G. Moscati
IRCCS Centro Cardiologico Monzino
Belgrade University School of Medicine
Vilniaus Universitetas
Università di Pisa
Slaski Uniwersytet Medyczny w Katowicach
Universidade da Coruña
Università degli studi di Bari Aldo Moro
Azienda Ospedaliera Careggi
Azienda Ospedaliero - Universitaria di Modena
Università degli Studi di Messina, Facoltà di Medicina e Chirurgia
Azienda Ospedaliera San Camillo Forlanini
Istituto di Fisiologia Clinica del CNR
Hospital de Clínicas "José de San Martín"
Medical University of Lodz
Mayo Clinic
Hospital Universitario Virgen Macarena
Research Scientific Cardiocenter “Medika”
Investigaciones Medicas Center
Ospedale Ruggi D' Aragona
Hospital Sao Vicente de Paulo e Hospital de Cidade
Hospital São José
Dolo Hospital
Fatebenefratelli Hospital of Benevento
Clinical Center
Cardiology Research lnstitute, Tomsk National Research Medical Center, Russian Academy of Sciences
Medical University of Lodz, Bieganski Hospital
Ospedale San Carlo, Potenza
Ospedale per gli Infermi di Faenza
Azienda Ospedaliera S.G. Moscati
IRCCS Centro Cardiologico Monzino
Belgrade University School of Medicine
Vilniaus Universitetas
Università di Pisa
Slaski Uniwersytet Medyczny w Katowicach
Universidade da Coruña
Università degli studi di Bari Aldo Moro
Azienda Ospedaliera Careggi
Azienda Ospedaliero - Universitaria di Modena
Università degli Studi di Messina, Facoltà di Medicina e Chirurgia
Azienda Ospedaliera San Camillo Forlanini
Istituto di Fisiologia Clinica del CNR
Hospital de Clínicas "José de San Martín"
Medical University of Lodz
Mayo Clinic
Hospital Universitario Virgen Macarena
Research Scientific Cardiocenter “Medika”
Investigaciones Medicas Center
Ospedale Ruggi D' Aragona
Hospital Sao Vicente de Paulo e Hospital de Cidade
Hospital São José
Dolo Hospital
Fatebenefratelli Hospital of Benevento
Clinical Center
Other Contributor(s)
Abstract
Background: Left atrial (LA) myopathy with paroxysmal and permanent atrial fibrillation (AF) is frequent in chronic coronary syndromes (CCS) but sometimes occult at rest and elicited by stress. Aim: This study sought to assess LA volume and function at rest and during stress across the spectrum of AF. Methods: In a prospective, multicenter, observational study design, we enrolled 3042 patients [age = 64 ± 12; 63.8% male] with known or suspected CCS: 2749 were in sinus rhythm (SR, Group 1); 191 in SR with a history of paroxysmal AF (Group 2); and 102 were in permanent AF (Group 3). All patients underwent stress echocardiography (SE). We measured left atrial volume index (LAVI) in all patients and LA Strain reservoir phase (LASr) in a subset of 486 patients. Results: LAVI increased from Group 1 to 3, both at rest (Group 1 = 27.6 ± 12.2, Group 2 = 31.6 ± 12.9, Group 3 = 43.3 ± 19.7 mL/m2, p < 0.001) and at peak stress (Group 1 = 26.2 ± 12.0, Group 2 = 31.2 ± 12.2, Group 3 = 43.9 ± 19.4 mL/m2, p < 0.001). LASr progressively decreased from Group 1 to 3, both at rest (Group 1 = 26.0 ± 8.5%, Group 2 = 23.2 ± 11.2%, Group 3 = 8.5 ± 6.5%, p < 0.001) and at peak stress (Group 1 = 26.9 ± 10.1, Group 2 = 23.8 ± 11.0 Group 3 = 10.7 ± 8.1%, p < 0.001). Stress B-lines (≥2) were more frequent in AF (Group 1 = 29.7% vs. Group 2 = 35.5% vs. Group 3 = 57.4%, p < 0.001). Inducible ischemia was less frequent in SR (Group 1 = 16.1% vs. Group 2 = 24.7% vs. Group 3 = 24.5%, p = 0.001). Conclusions: In CCS, rest and stress LA dilation and reservoir dysfunction are often present in paroxysmal and, more so, in permanent AF and are associated with more frequent inducible ischemia and pulmonary congestion during stress.