Xanthine Oxidase Inhibition by Monoterpene-Chalcone Conjugates from Kaempferia subglobosa and Molecular Docking Insights
Issued Date
2024-01-01
Resource Type
ISSN
18614728
eISSN
1861471X
Scopus ID
2-s2.0-85207668632
Journal Title
Chemistry - An Asian Journal
Rights Holder(s)
SCOPUS
Bibliographic Citation
Chemistry - An Asian Journal (2024)
Suggested Citation
Boonsombat J., Jongsomjainuk O., Thongnest S., Sirirak J., Batsomboon P., Ruchisansakun S., Prachya S., Mahidol C., Ruchirawat S. Xanthine Oxidase Inhibition by Monoterpene-Chalcone Conjugates from Kaempferia subglobosa and Molecular Docking Insights. Chemistry - An Asian Journal (2024). doi:10.1002/asia.202400677 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101899
Title
Xanthine Oxidase Inhibition by Monoterpene-Chalcone Conjugates from Kaempferia subglobosa and Molecular Docking Insights
Corresponding Author(s)
Other Contributor(s)
Abstract
Kaempferia subglobosa is a perennial medicinal plant in the Zingiberaceae family, identified as a new species in January 2024. To uncover the biological benefits of K. subglobosa and its compounds, investigation of the metabolites of the roots and rhizomes, yielded three new monoterpene-chalcone conjugates, the globosones A–C, representing a rare metabolite group within the Zingiberaceae, along with six known compounds. The biogenetic pathway for the globosones involves an oxidative [3+2] cycloaddition between α-phellandrene and 4’-methoxy-4,2’,6’-trihydroxychalcone. Biological testing revealed potent xanthine oxidase (XO) inhibition by globosones A and B, with IC50 values of 7.0±1.0 and 3.0±0.2 μM, respectively, surpassing the positive control drug allopurinol (IC50 7.2±0.1 μM). Globosones A–C also showed good aromatase inhibition (IC50 3.0–3.5 μM). Molecular docking studies indicated that globosones A and B may inhibit xanthine oxidase through binding at the FAD domain site. The physicochemical properties of these isolates suggest that they possess characteristics suitable for additional biological assessment in more advanced test systems. This study enhances an understanding of monoterpene-chalcone conjugate inhibitors of XO, and offers preliminary insights into the metabolites and bioactivities of K. subglobosa, uncovering potent biological activities associated with this newly discovered plant species.