Modeling the Interplay of Ghrelin, Leptin, and Exercise on Energy Balance: A Systems Dynamics Approach
Issued Date
2025-01-01
Resource Type
Scopus ID
2-s2.0-105032736870
Journal Title
Cinti 2025 IEEE 25th International Symposium on Computational Intelligence and Informatics Proceedings
Start Page
35
End Page
44
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SCOPUS
Bibliographic Citation
Cinti 2025 IEEE 25th International Symposium on Computational Intelligence and Informatics Proceedings (2025) , 35-44
Suggested Citation
Chudtong M., Nagy I., De Gaetano A. Modeling the Interplay of Ghrelin, Leptin, and Exercise on Energy Balance: A Systems Dynamics Approach. Cinti 2025 IEEE 25th International Symposium on Computational Intelligence and Informatics Proceedings (2025) , 35-44. 44. doi:10.1109/CINTI67731.2025.11311736 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115799
Title
Modeling the Interplay of Ghrelin, Leptin, and Exercise on Energy Balance: A Systems Dynamics Approach
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Corresponding Author(s)
Other Contributor(s)
Abstract
We detail a possible mathematical model describing the dynamics of key energy substrates, regulatory hormones, appetite, and fat mass incorporating the effect of exercise. The model describes physiological responses to three mixed meals (breakfast, lunch, dinner), represented by difference-ofexponential influx functions. The size of these meal pulses is modulated by appetite, which is dynamically regulated by ghrelin and leptin concentrations. The system is formulated as set of coupled nonlinear algebraic and ordinary differential equations (ODEs), including state variables for appetite, gut glucose and lipid contents, glycemia, lipidemia, insulinemia, plasma ghrelin and leptin concentrations, weight and fat mass, as well as the effect of exercise.