Optimal gestational weight gain and pregnancy outcomes, by BMI and height, in a marginalised population of women with short stature living along the Thailand-Myanmar border: A retrospective cohort, 2004–2023

Abstract

Background Existing gestational weight gain (GWG) standards may not be applicable to women of short stature and those who have limited access to healthcare and are vulnerable to compromised nutrition during pregnancy. To inform the development of population-specific recommendations, this study investigated optimal GWG, by height and Body Mass Index (BMI), in a minority migrant and refugee population living along the Thailand-Myanmar border. Methods Records of all women attending antenatal care in the first trimester at the Shoklo-Malaria Research Unit between 2004 and 2023 were retrospectively examined. GWG of 17,194 women was assessed against maternal, delivery and neonatal outcomes, by height and per Asia-Pacific BMI category. The Gestation Related Optimal Weight centiles were used to classify small, appropriate and large for gestational age neonates. Multivariable logistic regression analysis, including natural cubic splines, was used to assess the relationships between GWG and outcomes of interest. Optimal GWG per BMI group was defined as the GWG associated with the lowest composite risk for adverse outcomes. The optimal range included GWG values that did not exceed a 5% increase from the corresponding minimum composite risk. Results Optimal GWG in women shorter than 153 cm was lower per BMI group than the National Academy of Medicine and Intergrowth-21 recommendations: underweight 12.1 kg (10.0–14.5), normal 10.4 kg (8.0–12.9), overweight/obese 5.3 kg (3.1–8.5); but comparable for women 153 cm or more: underweight 13.1 kg (11.0–15.1), normal 12.3 kg (9.7–15.3), overweight/obese 9.5 kg (6.4–13.4). Conclusion Optimal GWG ranges are lower for this population with short stature compared to existing international guidelines. Clinical and contextual factors must be considered when implementing GWG recommendations for this, and other marginalized and short-stature populations.