Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)
Issued Date
2023-10-01
Resource Type
ISSN
18743900
eISSN
18767486
Scopus ID
2-s2.0-85166647160
Journal Title
Phytochemistry Letters
Volume
57
Start Page
1
End Page
4
Rights Holder(s)
SCOPUS
Bibliographic Citation
Phytochemistry Letters Vol.57 (2023) , 1-4
Suggested Citation
Olaranont Y., Cheek M., Mas-Claret E., Prescott T.A.K., Onana J.M., Langat M.K. Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae). Phytochemistry Letters Vol.57 (2023) , 1-4. 4. doi:10.1016/j.phytol.2023.07.010 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/88302
Title
Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)
Other Contributor(s)
Abstract
Leaves of herbarium specimen material of Vepris onanae, collected in Cameroon, have yielded two undescribed 2-quinolines, onanaenine A (1) and onanaenine B (2), alongside the known 6,7-dimethoxy-N-methylflindersine (3), evoxanthine (4), 6-methoxy-tecleanthine (5) and polybotrin. Compounds 1 and 2 were not cytotoxic against FM55 melanoma cells at a concentration up to 200 µM, and they did not show signs of stimulating fibroblast skin cells at concentrations, up to 20 µM. Vepris onanae, the source of the two new 2-quinoline alkaloids, is at high risk of extinction, being near-endemic to the threatened Bali-Ngemba forest of NW Region Cameroon. Bali Ngemba has already seen the global extinction of Vepris bali, before it could be researched for new compounds.