Hematologic Malignancies Among Adults in Southeast Asia: Incidence, Mortality, and Regional Contexts
1
Issued Date
2025-12-01
Resource Type
eISSN
26878941
Scopus ID
2-s2.0-105024984076
Pubmed ID
41397191
Journal Title
JCO Global Oncology
Volume
11
Rights Holder(s)
SCOPUS
Bibliographic Citation
JCO Global Oncology Vol.11 (2025) , e2500206
Suggested Citation
Feliciano E.J.G., Jain U., Dee E.C., Selokar A., Baclay J.R., Wu J.F., Ho F.D.V., Jain B., Patel T.A., Swami N., Yee K., Lapen K., Columbres R.C., Bhatt N., Go A.E., Imber B.S., Chitapanarux I., Ting F.I.L., Tremblay D., Singh A., Santosa D., Chuncharunee S., Gan G.G., Bhoo-Pathy N. Hematologic Malignancies Among Adults in Southeast Asia: Incidence, Mortality, and Regional Contexts. JCO Global Oncology Vol.11 (2025) , e2500206. doi:10.1200/GO-25-00206 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113645
Title
Hematologic Malignancies Among Adults in Southeast Asia: Incidence, Mortality, and Regional Contexts
Author's Affiliation
Stanford University
University of Cambridge
University of Pennsylvania
University of California, San Diego
Stanford University School of Medicine
Icahn School of Medicine at Mount Sinai
University of Pittsburgh School of Medicine
National Cancer Institute (NCI)
Memorial Sloan-Kettering Cancer Center
Universiti Malaya
Medical College of Wisconsin
Penn Medicine
Universitas Diponegoro
Faculty of Medicine, Chiang Mai University
Ramathibodi Hospital
Ateneo de Manila University
Singapore Health Services
University of the Philippines College of Medicine
WCU College of Osteopathic Medicine
University of St. La Salle
Cebu Institute of Medicine
Philippine Institute for Development Studies
Corazon Locsin Montelibano Memorial Regional Hospital
University of Cambridge
University of Pennsylvania
University of California, San Diego
Stanford University School of Medicine
Icahn School of Medicine at Mount Sinai
University of Pittsburgh School of Medicine
National Cancer Institute (NCI)
Memorial Sloan-Kettering Cancer Center
Universiti Malaya
Medical College of Wisconsin
Penn Medicine
Universitas Diponegoro
Faculty of Medicine, Chiang Mai University
Ramathibodi Hospital
Ateneo de Manila University
Singapore Health Services
University of the Philippines College of Medicine
WCU College of Osteopathic Medicine
University of St. La Salle
Cebu Institute of Medicine
Philippine Institute for Development Studies
Corazon Locsin Montelibano Memorial Regional Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
PURPOSE: Southeast Asia (SEA), home to over 690 million people across 11 countries-Brunei, Cambodia, Indonesia, Lao PDR, Malaysia, Myanmar, the Philippines, Singapore, Thailand, Timor-Leste, and Vietnam-features diverse socioeconomic contexts and cancer care landscapes. We report and interpret incidence and mortality statistics for hematologic malignancies (HMs) in SEA. METHODS: We analyzed 2022 Global Cancer Observatory data from the International Agency for Research on Cancer to report age-standardized incidence rate (ASIR) and age-standardized mortality rates (ASMR) per 100,000 individuals age 20 years and older. We focused on non-Hodgkin lymphoma (NHL), leukemia, multiple myeloma (MM), and Hodgkin lymphoma (HL), standardized using Segi-Doll world population estimates. RESULTS: Across 11 Southeast Asian countries, age-standardized incidence and mortality rates (ASIRs and ASMRs) for HMs vary widely, highlighting significant regional disparities. Singapore consistently reports the highest ASIRs for NHL, leukemia, MM, and HL, yet its ASMRs are much lower, reflecting strong health care infrastructure. Thailand, Brunei, and Malaysia mirror these associations, which are particularly pronounced in NHL and HL. In contrast, for leukemia and MM, Brunei, Cambodia, Indonesia, Lao PDR, Malaysia, Myanmar, the Philippines, Timor-Leste, and Vietnam demonstrated lower ASIR and ASMR that approaches ASIR, suggesting barriers to diagnosis and survivorship. Time trends suggest increasing mortality from MM and NHL, particularly in Thailand and the Philippines. Overall, survival outcomes correlate strongly with national health care capacity. CONCLUSION: Higher reported incidence in wealthier SEA countries may reflect greater diagnostic capacity, whereas similar incidence and mortality in low-income countries likely indicates limited access to timely diagnosis and treatment. Mortality patterns underscore the region's broad disparities in cancer care infrastructure and outcomes, shaped by socioeconomic and systemic health inequities.