Source-specific short-term-ozone exposure and specific cancer mortality risk: A multi-country study in 11,215 communities
1
Issued Date
2026-05-01
Resource Type
ISSN
03043894
eISSN
18733336
Scopus ID
2-s2.0-105034738095
Journal Title
Journal of Hazardous Materials
Volume
508
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Hazardous Materials Vol.508 (2026)
Suggested Citation
Yu P., Xu R., Huang W., Liu Y., Yang Z., Abramson M.J., Lavigne E., Hales S., Morawska L., Saldiva P.H.N., Johnston F.H., Knibbs L., Morgan G., Marks G.B., Heyworth J., Kim H., Tantrakarnapa K., Kliengchuay W., Matus P., Coelho M.S.Z.S., Zhou S., Ye T., Yu W., Ju K., Zhang Y., Wu Y., Wen B., Xu Z., Li S., Guo Y. Source-specific short-term-ozone exposure and specific cancer mortality risk: A multi-country study in 11,215 communities. Journal of Hazardous Materials Vol.508 (2026). doi:10.1016/j.jhazmat.2026.141822 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116124
Title
Source-specific short-term-ozone exposure and specific cancer mortality risk: A multi-country study in 11,215 communities
Author's Affiliation
Universidade de São Paulo
Monash University
UNSW Sydney
Seoul National University
The University of Western Australia
University of Ottawa
Queensland University of Technology
University of Otago
The University of Sydney School of Public Health
Health Canada
Faculty of Tropical Medicine, Mahidol University
Universidad de los Andes, Chile
Menzies Institute for Medical Research
Sydney Local Health District
Chongqing Emergency Medical Center
Monash University
UNSW Sydney
Seoul National University
The University of Western Australia
University of Ottawa
Queensland University of Technology
University of Otago
The University of Sydney School of Public Health
Health Canada
Faculty of Tropical Medicine, Mahidol University
Universidad de los Andes, Chile
Menzies Institute for Medical Research
Sydney Local Health District
Chongqing Emergency Medical Center
Corresponding Author(s)
Other Contributor(s)
Abstract
AbstractOzone (O<inf>3</inf>) exposure is a recognised risk factor for respiratory and cardiovascular mortality, but its short-term effects on cancer remain largely unknown due to the absence of large-scale, multi-country evidence. Based on 9233,612 cancer deaths from 2000 to 2019 across 11,215 communities in Australia, Brazil, Canada, Chile, South Korea, Mexico, New Zealand and Thailand, this study provides the first comprehensive multi-country assessment of the associations between short-term O<inf>3</inf> exposure and mortality from a wide range of cancer types, together with the contributions of major emission sources. Daily maximum 8-hour O<inf>3</inf> concentrations were linked to residential locations and analysed using a space-time-stratified case-crossover design, with source-specific contributions from traffic, landscape fires and industrial emissions quantified. Each 10 μg/m3 increase in O<inf>3</inf> (lag 0–1 days) was associated with a 0.84% (95% CI: 0.77–0.91%) increase in all-cancer mortality, with elevated risks observed for 24 cancer types except for nasopharyngeal, testicular cancer, and leukemia. Effect estimates varied by cancer type, ranging from a 0.42% increase for liver cancer to a 1.43% increase for thyroid cancer per 10 μg/m3 rise in O<inf>3</inf> exposure. Short-term O<inf>3</inf> exposure accounted for 6.37% (5.84–6.91%) of all cancer deaths, with the largest attributable fractions in Brazil (10.8%), Chile (6.3%) and Thailand (6.0%). Traffic emissions were the dominant contributor to O<inf>3</inf>-attributable cancer deaths overall, while landscape fire-related O<inf>3</inf> contributed substantially in Australia and Brazil. These findings reveal a significant and previously under-recognised short-term impact of O<inf>3</inf> exposure on cancer mortality and identify key emission sources driving this burden. The results provide important evidence for air-quality management and targeted cancer prevention strategies in diverse global regions.