Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study
Issued Date
2023-05-01
Resource Type
ISSN
01651781
eISSN
18727123
Scopus ID
2-s2.0-85151411106
Pubmed ID
37015164
Journal Title
Psychiatry Research
Volume
323
Rights Holder(s)
SCOPUS
Bibliographic Citation
Psychiatry Research Vol.323 (2023)
Suggested Citation
Fusar-Poli L. Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. Psychiatry Research Vol.323 (2023). doi:10.1016/j.psychres.2023.115184 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81568
Title
Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study
Author(s)
Author's Affiliation
Instituto de Investigación Sanitaria del Principado de Asturias
Ramathibodi Hospital
University of Health Sciences
Centro de Investigación Biomédica En Red de Salud Mental
Klinicki Centar Srbije
Institut za mentalno zdravlje
Belgrade University School of Medicine
Hospital General Universitario Gregorio Marañon
University Medical Center Utrecht
Universidad de Santiago de Compostela
Hospital Virgen de La Luz de Cuenca
Cardiff University
Adnan Menderes Üniversitesi
Universiteit Maastricht
Yale School of Medicine
Hospital Clinico Universitario de Valencia
Università degli Studi di Pavia
Dokuz Eylül Üniversitesi
Ankara Üniversitesi
İstanbul Tıp Fakültesi
King's College London
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS
Facultad de Medicina y Ciencias de la Salud
Middle East Technical University (METU)
Complejo Hospitalario Universitario de Santiago
Universitat de Barcelona
Universidad de Castilla-La Mancha
Mondriaan Mental Health Trust
Neuroscience and Neurotechnology Center of Excellence (NÖROM)
Güven Çayyolu Healthcare Campus
GGNet Mental Health
Special Hospital for Psychiatric Disorders Kovin
Turkish Federation of Schizophrenia Associations
Fundación Pública Galega de Medicina Xenómica (SERGAS)
Mental Health Services of Principado de Asturias
Gulhane Medical Faculty
Ramathibodi Hospital
University of Health Sciences
Centro de Investigación Biomédica En Red de Salud Mental
Klinicki Centar Srbije
Institut za mentalno zdravlje
Belgrade University School of Medicine
Hospital General Universitario Gregorio Marañon
University Medical Center Utrecht
Universidad de Santiago de Compostela
Hospital Virgen de La Luz de Cuenca
Cardiff University
Adnan Menderes Üniversitesi
Universiteit Maastricht
Yale School of Medicine
Hospital Clinico Universitario de Valencia
Università degli Studi di Pavia
Dokuz Eylül Üniversitesi
Ankara Üniversitesi
İstanbul Tıp Fakültesi
King's College London
Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS
Facultad de Medicina y Ciencias de la Salud
Middle East Technical University (METU)
Complejo Hospitalario Universitario de Santiago
Universitat de Barcelona
Universidad de Castilla-La Mancha
Mondriaan Mental Health Trust
Neuroscience and Neurotechnology Center of Excellence (NÖROM)
Güven Çayyolu Healthcare Campus
GGNet Mental Health
Special Hospital for Psychiatric Disorders Kovin
Turkish Federation of Schizophrenia Associations
Fundación Pública Galega de Medicina Xenómica (SERGAS)
Mental Health Services of Principado de Asturias
Gulhane Medical Faculty
Other Contributor(s)
Abstract
Background: People with schizophrenia spectrum disorders (SSD) frequently present cognitive impairments. Here, we investigated whether the exposome score for schizophrenia (ES-SCZ) - a cumulative environmental exposure score - was associated with impairments of neurocognition, social cognition, and perception in patients with SSD, their unaffected siblings, and healthy controls. Methods: This cross-sectional sample consisted of 1200 patients, 1371 siblings, and 1564 healthy controls. Neurocognition, social cognition, and perception were assesed using a short version of the Wechsler Adult Intelligence Scale–Third Edition (WAIS-III), the Degraded Facial Affect Recognition Task (DFAR), and the Benton Facial Recognition Test (BFR), respectively. Regression models were used to analyze the association between ES-SCZ and cognitive domains in each group. Results: There were no statistically significant associations between ES-SCZ and cognitive domains in SSD. ES-SCZ was negatively associated with T-score of cognition in siblings (B=-0.40, 95% CI -0.76 to -0.03) and healthy controls (B=-0.63, 95% CI -1.06 to -0.21). Additionally, ES-SCZ was positively associated with DFAR-total in siblings (B=0.83, 95% CI 0.26 to 1.40). Sensitivity analyses excluding cannabis use history from ES-SCZ largely confirmed the main findings. Conclusions: Longitudinal cohorts may elucidate how environmental exposures influence the onset and course of cognitive impairments in trans-syndromic psychosis spectrum.