Effect of Influenza Vaccination on Mortality and Heart Failure Hospitalization in Heart Failure Patients
Issued Date
2025-10-01
Resource Type
eISSN
2076393X
Scopus ID
2-s2.0-105020047141
Journal Title
Vaccines
Volume
13
Issue
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Vaccines Vol.13 No.10 (2025)
Suggested Citation
Maneesopit C., Phrommintikul A., Bruminhent J., Thakkinstian A., Yingchoncharoen T. Effect of Influenza Vaccination on Mortality and Heart Failure Hospitalization in Heart Failure Patients. Vaccines Vol.13 No.10 (2025). doi:10.3390/vaccines13101055 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112912
Title
Effect of Influenza Vaccination on Mortality and Heart Failure Hospitalization in Heart Failure Patients
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: The association of influenza vaccination and heart failure (HF) hospitalization and mortality in Thai HF patients is unknown. Objective: We wished to investigate associations between receiving an influenza vaccine and all-cause death or HF hospitalization in HF patients. Methods: We retrospectively reviewed medical records from two large tertiary-care centers in Thailand (Ramathibodi Hospital and Maharaj Nakorn Chiang Mai Hospital) with newly diagnosed heart failure between 2013 and 2020 in an outpatient clinic. We examined the relationship between influenza vaccination and outcomes in a propensity-adjusted model. Results: Of 588 patients, 181 (31%) received an influenza vaccination. During a median follow-up of 57 months, influenza vaccination was associated with a 56% reduction in the risk of HF hospitalization or death (HF hospitalization or all-cause death: HR: 0.44; 95% CI: 0.31–0.63; p < 0.001) in an unadjusted analysis. After propensity score adjustment, influenza vaccination, however, was not associated with a reduced risk of all-cause death but was associated with a reduced risk of HF hospitalization (ATE: 3.06 years; 95% CI: 0.14 to 5.98; p = 0.04). Conclusions: In patients with HF, influenza vaccination was not associated with a reduced risk of the composite of all-cause death or HF hospitalization after adjustment for confounders.