Pyranonaphthoquinones and Naphthoquinones from the Stem Bark of Ventilago harmandiana and Their Anti-HIV-1 Activity
Issued Date
2023-03-24
Resource Type
ISSN
01633864
eISSN
15206025
Scopus ID
2-s2.0-85151043318
Pubmed ID
36787536
Journal Title
Journal of Natural Products
Volume
86
Issue
3
Start Page
498
End Page
507
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Natural Products Vol.86 No.3 (2023) , 498-507
Suggested Citation
Saisin S., Panthong K., Hongthong S., Kuhakarn C., Thanasansurapong S., Chairoungdua A., Suksen K., Akkarawongsapat R., Napaswad C., Prabpai S., Nuntasaen N., Reutrakul V. Pyranonaphthoquinones and Naphthoquinones from the Stem Bark of Ventilago harmandiana and Their Anti-HIV-1 Activity. Journal of Natural Products Vol.86 No.3 (2023) , 498-507. 507. doi:10.1021/acs.jnatprod.2c00980 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81621
Title
Pyranonaphthoquinones and Naphthoquinones from the Stem Bark of Ventilago harmandiana and Their Anti-HIV-1 Activity
Other Contributor(s)
Abstract
Seven previously undescribed compounds, including five pyranonaphthoquinones (ventilanones L-P) and two naphthoquinones (ventilanones Q and R), along with 15 known compounds were isolated from the stem bark of Ventilago harmandiana (Rhamnaceae). The structures were established by extensive analysis of their spectroscopic data. The absolute configuration of ventilanone L was established from single crystal X-ray crystallographic analysis using Cu Kα radiation and from its electronic circular dichroism data. Anti-HIV-1 activity using a syncytium inhibition assay and the cytotoxic activities of some isolated compounds were evaluated. Compounds 12, 13, 15, and 16 showed activity against syncytium formation with half maximal effective concentration (EC50) values ranging from 9.9 to 47 μM (selectivity index (SI) 2.4-4.5).