Course and predictors of disability in Thai patients with schizophrenia: A 2-year, multi-center, prospective, observational study
Issued Date
2022-04-01
Resource Type
ISSN
18762018
eISSN
18762026
Scopus ID
2-s2.0-85125122212
Pubmed ID
35219052
Journal Title
Asian Journal of Psychiatry
Volume
70
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Journal of Psychiatry Vol.70 (2022)
Suggested Citation
Srisurapanont M., Kunchanaphongphan T., Chokemaitree N., Prachason T., Kanchanatawan B., Suttajit S., Sanguanvichaikul T., Trisukon W., Dendumrongkul P., Chinvararak C., Kawilapat S. Course and predictors of disability in Thai patients with schizophrenia: A 2-year, multi-center, prospective, observational study. Asian Journal of Psychiatry Vol.70 (2022). doi:10.1016/j.ajp.2022.103044 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85997
Title
Course and predictors of disability in Thai patients with schizophrenia: A 2-year, multi-center, prospective, observational study
Other Contributor(s)
Abstract
Purpose: This 2-year, multi-center, prospective, observational study aimed to describe the course and examine baseline characteristics for predicting disability in Thai patients with schizophrenia. Methods: Participants were patients with schizophrenia aged 18–65 years receiving treatment in five tertiary hospitals. Disability was defined by a score of 10 or more of the 12-item World Health Organization Disability Assessment Schedule, version 2.0 (12-item WHODAS 2.0). Other data being collected included socio-demographic data, course of illness, antipsychotics, antipsychotic drug attitudes, behavioral/psychiatric symptoms, alcohol use, social supports, and quality of life at five visits, including weeks 0 (baseline), 24, 48, 72, and 96. Results: Of the 158 enrolled patients, we analyzed the data of 119 participants who were reassessed at least once during the follow-up. These 119 participants (70% male) had median age and age at psychotic onset of 38 and 22 years, respectively. Disability was found in 43 (36.1%) participants at baseline and 72 (64.7%) participants at week 96. The median [interquartile ranges] WHODAS scores at five time points were 6 [3–12], 9 [4–13], 10 [6–10], 10 [4–10], and 10 [6–10], respectively (p < 0.001). The multivariate logistic regression analysis revealed that duration of psychosis (adjusted odds ratio = 1.08, 95%CI = 1.04 – 1.14, p = 0.001) and depression (adjusted odds ratio = 3.54, 95%CI = 1.14 – 11.06, p = 0.029) at baseline predicted 2-year disability. Conclusions: Thai patients with schizophrenia had an increase in disability over a 2-year follow-up period. Duration of psychosis and depression were predictors of disability in these patients.