Combination of curcumin or chitosan with photodynamic therapy as an effective alternative therapy for overcoming wound infection associated with multidrug-resistant Acinetobacter baumannii
Issued Date
2025-06-01
Resource Type
eISSN
29501946
Scopus ID
2-s2.0-105005853397
Journal Title
Microbe (Netherlands)
Volume
7
Rights Holder(s)
SCOPUS
Bibliographic Citation
Microbe (Netherlands) Vol.7 (2025)
Suggested Citation
Yonpiam M., Wannigama D.L., Shein A.M.S., Liao T., Hurst C., Monk P.N., Amarasiri M., Phattharapornjaroen P., Ounjai P., Saethang T., Badavath V.N., Luk-in S., Nilgate S., Rirerm U., Srisakul S., Ngamwongsatit N., Leelahavanichkul A., Ragupathi N.K.D., Kanjanabuch T., Narkban P., Miyanaga K., Cui L., Boontaveeyuwat E., Higgins P.G., Kicic A., Hamamoto H., Abe S., Hongsing P., Chatsuwan T. Combination of curcumin or chitosan with photodynamic therapy as an effective alternative therapy for overcoming wound infection associated with multidrug-resistant Acinetobacter baumannii. Microbe (Netherlands) Vol.7 (2025). doi:10.1016/j.microb.2025.100375 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/110426
Title
Combination of curcumin or chitosan with photodynamic therapy as an effective alternative therapy for overcoming wound infection associated with multidrug-resistant Acinetobacter baumannii
Author(s)
Yonpiam M.
Wannigama D.L.
Shein A.M.S.
Liao T.
Hurst C.
Monk P.N.
Amarasiri M.
Phattharapornjaroen P.
Ounjai P.
Saethang T.
Badavath V.N.
Luk-in S.
Nilgate S.
Rirerm U.
Srisakul S.
Ngamwongsatit N.
Leelahavanichkul A.
Ragupathi N.K.D.
Kanjanabuch T.
Narkban P.
Miyanaga K.
Cui L.
Boontaveeyuwat E.
Higgins P.G.
Kicic A.
Hamamoto H.
Abe S.
Hongsing P.
Chatsuwan T.
Wannigama D.L.
Shein A.M.S.
Liao T.
Hurst C.
Monk P.N.
Amarasiri M.
Phattharapornjaroen P.
Ounjai P.
Saethang T.
Badavath V.N.
Luk-in S.
Nilgate S.
Rirerm U.
Srisakul S.
Ngamwongsatit N.
Leelahavanichkul A.
Ragupathi N.K.D.
Kanjanabuch T.
Narkban P.
Miyanaga K.
Cui L.
Boontaveeyuwat E.
Higgins P.G.
Kicic A.
Hamamoto H.
Abe S.
Hongsing P.
Chatsuwan T.
Author's Affiliation
Yamagata Prefectural Central Hospital
Medizinische Fakultät
Faculty of Science, Mahidol University
UWA Medical School
Perth Children's Hospital
Jichi Medical University
The Faculty of Health Sciences
Narsee Monjee Institute of Management Studies, Mumbai
Chulalongkorn University
Yamagata University Faculty of Medicine
Chulabhorn Royal Academy
King Chulalongkorn Memorial Hospital
Kasetsart University
Faculty of Medicine, Thammasat University
Mahidol University
Thammasat University
The Sheffield Medical School
Tohoku University
Faculty of Medicine, Chulalongkorn University
The University of Sheffield
The Kids Research Institute Australia
Bioberrys Healthcare and Research Centre
Partner Site Bonn-Cologne
Medizinische Fakultät
Faculty of Science, Mahidol University
UWA Medical School
Perth Children's Hospital
Jichi Medical University
The Faculty of Health Sciences
Narsee Monjee Institute of Management Studies, Mumbai
Chulalongkorn University
Yamagata University Faculty of Medicine
Chulabhorn Royal Academy
King Chulalongkorn Memorial Hospital
Kasetsart University
Faculty of Medicine, Thammasat University
Mahidol University
Thammasat University
The Sheffield Medical School
Tohoku University
Faculty of Medicine, Chulalongkorn University
The University of Sheffield
The Kids Research Institute Australia
Bioberrys Healthcare and Research Centre
Partner Site Bonn-Cologne
Corresponding Author(s)
Other Contributor(s)
Abstract
The increasing prevalence of multidrug-resistant Acinetobacter baumannii as an opportunistic pathogen in wound infections raises significant concerns due to its antibiotic resistance and biofilm-mediated antibiotic tolerance. This underscores the urgent need to explore an alternative approach to effectively managing wound infections caused by MDR A. baumannii. In this study, combining subinhibitory concentrations of curcumin (25 µg/ml) or chitosan (156 µg/ml) with photodynamic therapy-PDT (10 J/cm2) resulted in a significant reduction of planktonic viabilities and biofilm biovolume of MDR A. baumannii clinical isolates in vitro. In murine A. baumannii-associated wound infection, a combination of curcumin (25 µg/ml) or chitosan (156 µg/ml) with PDT (10 J/cm2) resulted in complete bacterial eradication with wound healing at Day 15 of post-treatments with these combination therapies. Our study demonstrated that combining curcumin or chitosan with PDT at their subinhibitory concentrations represents a promising alternative strategy as localized therapy for effectively managing A. baumannii-associated wound infection.