The study of tryptophol containing emulgel on fungal reduction and skin irritation
1
Issued Date
2023-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85175691635
Journal Title
Scientific Reports
Volume
13
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.13 No.1 (2023)
Suggested Citation
Kitisin T., Muangkaew W., Thitipramote N., Pudgerd A., Sukphopetch P. The study of tryptophol containing emulgel on fungal reduction and skin irritation. Scientific Reports Vol.13 No.1 (2023). doi:10.1038/s41598-023-46121-z Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/91037
Title
The study of tryptophol containing emulgel on fungal reduction and skin irritation
Author's Affiliation
Other Contributor(s)
Abstract
Tryptophol (TOH), a fungal quorum-sensing molecule, that possesses anti-fungal activities for controlling the growth of human pathogenic fungi. In the present study, we developed TOH-containing emulgel formulations and examined the antifungal activities and potential use as topical treatments on the skin. The results showed that TOH-containing emulgel at 1000 μM has excellent physical characteristics as homogenous, stability, and inhibits the growth of 30 species of human pathogenic fungi in vitro. TOH-containing emulgel did not cause skin irritation in mouse model of irritation and in healthy human volunteers. Moreover, an increase in skin hydration and a decrease in trans-epidermal water loss (TEWL) were observed after TOH-containing emulgel treatment on human skin. Our findings indicated that TOH-containing emulgel can be utilize as an antifungal agent for topical treatment against fungal infections on the skin.