Systemic drug induced photosensitivity
Issued Date
2024
Copyright Date
2020
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xi, 64 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thematic Paper (M.Sc. (Medicine))--Mahidol University, 2020
Suggested Citation
Deki, Kuenzang, 1989- Systemic drug induced photosensitivity. Thematic Paper (M.Sc. (Medicine))--Mahidol University, 2020. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/92131
Title
Systemic drug induced photosensitivity
Author(s)
Advisor(s)
Abstract
Drug-induced photosensitivity refers to the adverse cutaneous response to exogenous agents after exposure to ultraviolet radiation or visible light. It is classified into two types based on their pathogenesis: phototoxic reaction and photoallergic reaction. It is an uncommon dermatological problem and is often misdiagnosed, underdiagnosed, or underreported. This study is a literature review of the available English language literature on drug-induced photosensitivity from systemic drugs, the mechanism involved, clinical presentations, diagnosis, prevention, and management. Drugs commonly reported for inducing photosensitivity are hydrochlorothiazide, voriconazole, vemurafenib, tetracyclines (doxycycline, tetracycline), NSAIDs (ketoprofen, naproxen, piroxicam), quinolones (nalidixic acid, ciprofloxacin, lomefloxacin), chlorpromazine, and amiodarone. Phototoxic reaction results from direct cellular damage that typically presents as a sunburn like reaction. Photoallergic reaction is a delayed hypersensitivity reaction that presents as an eczematous eruption. Diagnosis is mainly based on the history of drug intake and sun exposure and the appearance of cutaneous eruption primarily affecting sun-exposed areas of the body. Phototesting, photopatch testing, and rechallenge testing can aid in the diagnosis when the relationship between drug intake and rash onset is unclear. The mainstay of management is the discontinuation of the culprit drug. Prevention includes informing patients on the risk of photosensitivity and advising on sun protection and avoidance
Description
Medicine (Mahidol University 2020)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Medicine Ramathibodi Hospital
Degree Discipline
Medicine
Degree Grantor(s)
Mahidol University