Chemical composition and cytotoxicity of the essential oil of Calophyllum fraseri M.R.Hend. & Wyatt-Sm
Issued Date
2026-01-01
Resource Type
ISSN
14786419
eISSN
14786427
Scopus ID
2-s2.0-105029246380
Journal Title
Natural Product Research
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research (2026)
Suggested Citation
Zaini N.N.M., Salleh W.M.N.H.W., Ghani N.A., Salihu A.S., Arzmi M.H., Kumsang P., Nutho B., Eshboev F., Kuziev S., Khasanov F. Chemical composition and cytotoxicity of the essential oil of Calophyllum fraseri M.R.Hend. & Wyatt-Sm. Natural Product Research (2026). doi:10.1080/14786419.2026.2625898 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/114992
Title
Chemical composition and cytotoxicity of the essential oil of Calophyllum fraseri M.R.Hend. & Wyatt-Sm
Author's Affiliation
Universiti Teknologi MARA
Faculty of Science, Mahidol University
Universiti Pendidikan Sultan Idris
National University of Uzbekistan named after Mirzo Ulugbek
Alfraganus University
International Islamic University Malaysia, Kulliyyah of Dentistry
Umaru Musa YarAdua University
Institute for Advanced Studies, New Uzbekistan University
Faculty of Science, Mahidol University
Universiti Pendidikan Sultan Idris
National University of Uzbekistan named after Mirzo Ulugbek
Alfraganus University
International Islamic University Malaysia, Kulliyyah of Dentistry
Umaru Musa YarAdua University
Institute for Advanced Studies, New Uzbekistan University
Corresponding Author(s)
Other Contributor(s)
Abstract
This study investigates the chemical composition and cytotoxicity potential of Calophyllum fraseri M.R.Hend. & Wyatt-Sm essential oil, complemented by molecular docking analysis. Gas chromatography-flame ionisation detection (GC-FID) and gas chromatography-mass spectrometry (GC-MS) identified 15 components, representing 93.1% of the total oil content. The major components were β-caryophyllene (19.4%), α-cubebene (18.3%), δ-cadinene (14.0%), α-humulene (10.3%), and γ-muurolene (9.5%). The essential oil exhibited weak cytotoxic activity against HepG2, MCF-7, and A549 cancer cell lines, with IC<inf>50</inf> values of 93.4 ± 0.15 μg/mL (HepG2), 89.2 ± 0.11 μg/mL (MCF-7), and 96.3 ± 0.12 μg/mL (A549). Molecular docking results revealed favourable interactions between γ-muurolene and Akt1, α-humulene and oestrogen receptor α (ERα), and α-cubebene and the epidermal growth factor receptor tyrosine kinase (EGFR-TK) domain. These docking results provide supportive molecular insights into potential target interactions of individual constituents rather than direct predictors of the biological activity of the crude essential oil.