Disclosure of HIV status and associated clinical outcomes of children and adolescents living with HIV in Asia
Issued Date
2023-01-01
Resource Type
ISSN
09540121
eISSN
13600451
Scopus ID
2-s2.0-85148440495
Pubmed ID
36794343
Journal Title
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Rights Holder(s)
SCOPUS
Bibliographic Citation
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV (2023)
Suggested Citation
Sornillo J.B., Ditangco R., Lumbiganon P., Vu T.A., Le O.N., Truong K.H., Nguyen L.V., Do V.C., Ounchanum P., Wati D.K., Puthanakit T., Kurniati N., Lapphra K., Sudjaritruk T., Kumarasamy N., Jamal Mohamed T.A., Nik Yusoff N.K., Fong S.M., Nallusamy R.A., Sohn A.H., Kariminia A. Disclosure of HIV status and associated clinical outcomes of children and adolescents living with HIV in Asia. AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV (2023). doi:10.1080/09540121.2023.2176424 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82291
Title
Disclosure of HIV status and associated clinical outcomes of children and adolescents living with HIV in Asia
Author's Affiliation
Siriraj Hospital
VHS Medical Centre India
Gokila
Vietnam National Children's Hospital
Children's Hospital No. 1 Ho Chi Minh City
Universitas Udayana
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
Faculty of Medicine, Chiang Mai University
The Kirby Institute
Faculty of Medicine, Khon Kaen University
Kuala Lumpur Hospital
Pantai Holdings Sdn Bhd
Faculty of Medicine, Chulalongkorn University
Worldwide Orphans Foundation
Children's Hospital 2
amfAR - The Foundation for AIDS Research
Hospital Raja Perempuan Zainab II
Chiangrai Prachanukroh Hospital
Hospital Likas
VHS Medical Centre India
Gokila
Vietnam National Children's Hospital
Children's Hospital No. 1 Ho Chi Minh City
Universitas Udayana
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
Faculty of Medicine, Chiang Mai University
The Kirby Institute
Faculty of Medicine, Khon Kaen University
Kuala Lumpur Hospital
Pantai Holdings Sdn Bhd
Faculty of Medicine, Chulalongkorn University
Worldwide Orphans Foundation
Children's Hospital 2
amfAR - The Foundation for AIDS Research
Hospital Raja Perempuan Zainab II
Chiangrai Prachanukroh Hospital
Hospital Likas
Other Contributor(s)
Abstract
Disclosure of HIV status is an important part of pediatric care. We studied disclosure and clinical outcomes in a multi-country Asian cohort of children and adolescents with HIV. Those 6–19 years of age who initiated combination antiretroviral therapy (cART) between 2008 and 2018, and who had at least one follow-up clinic visit were included. Data up to December 2019 were analyzed. Cox and competing risk regression analyses were used to assess the effect of disclosure on disease progression (WHO clinical stage 3 or 4), loss to follow-up (LTFU; > 12 months), and death. Of 1913 children and adolescents (48% female; median [IQR] age 11.5 [9.2–14.7] years at last clinic visit), 795 (42%) were disclosed to about their HIV status at a median age of 12.9 years (IQR: 11.8–14.1). During follow-up, 207 (11%) experienced disease progression, 75 (3.9%) were LTFU, and 59 (3.1%) died. There were lower hazards of disease progression (adjusted hazard ratio [aHR] 0.43 [0.28–0.66]) and death (aHR 0.36 [0.17–0.79]) for those disclosed to compared with those who were not. Disclosure and its appropriate implementation should be promoted in pediatric HIV clinics in resource-limited settings.