α-Glucosidase Inhibitory Activity and Anti-Adipogenic Effect of Compounds from Dendrobium delacourii
Issued Date
2022-02-01
Resource Type
eISSN
14203049
Scopus ID
2-s2.0-85124598010
Pubmed ID
35208957
Journal Title
Molecules
Volume
27
Issue
4
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules Vol.27 No.4 (2022)
Suggested Citation
Thant M.T., Khine H.E.E., Nealiga J.Q.L., Chatsumpun N., Chaotham C., Sritularak B., Likhitwitayawuid K. α-Glucosidase Inhibitory Activity and Anti-Adipogenic Effect of Compounds from Dendrobium delacourii. Molecules Vol.27 No.4 (2022). doi:10.3390/molecules27041156 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83835
Title
α-Glucosidase Inhibitory Activity and Anti-Adipogenic Effect of Compounds from Dendrobium delacourii
Author's Affiliation
Other Contributor(s)
Abstract
Chemical investigation of Dendrobium delacourii revealed 11 phenolic compounds, and the structures of these compounds were determined by analysis of their NMR and HR-ESI-MS data. All compounds were investigated for their α-glucosidase inhibitory activity and anti-adipogenic properties. Phoyunnanin E (10) and phoyunnanin C (11) showed the most potent α-glucosidase inhibition by comparing with acarbose, which was used as a positive control. Kinetic study revealed the non-competitive inhibitors against the enzyme. For anti-adipogenic activity, densifloral B (3) showed the strongest inhibition when compared with oxyresveratrol (positive control). In addition, densifloral B might be responsible for the inhibition of adipocyte differentiation via downregulating the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer-binding protein alpha (C/EBPα), which are major transcription factors in adipogenesis.