Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis
Issued Date
2024-02-01
Resource Type
eISSN
15577716
Scopus ID
2-s2.0-85169154898
Pubmed ID
37125449
Journal Title
Antioxidants & redox signaling
Volume
40
Issue
4-6
Start Page
222
End Page
235
Rights Holder(s)
SCOPUS
Bibliographic Citation
Antioxidants & redox signaling Vol.40 No.4-6 (2024) , 222-235
Suggested Citation
Kotepui K.U., Mueangson O., Mala W., Mahittikorn A., Wangdi K., Kotepui M. Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis. Antioxidants & redox signaling Vol.40 No.4-6 (2024) , 222-235. 235. doi:10.1089/ars.2023.0273 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97350
Title
Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis
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Corresponding Author(s)
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Abstract
Aims: The evidence of superoxide dismutase (SOD) in the pathogenesis of malaria is inconsistent. This study aimed to synthesize the evidence of blood levels of SOD in patients with malaria and determine the association of blood levels of SOD with the severity of malaria. Results: A total of 1874 articles were retrieved from database searches and 28 studies were included in the review. The blood levels of SOD were lower in individuals with malaria compared with those without malaria infection (p < 0.01, Cohen's d: -2.06, 95% CI: -2.99 to -1.14), I2: 98.96%, 2181 malaria cases/1186 uninfected cases). There were no differences in blood levels of SOD between severe and nonsevere malaria patients (p = 0.09, Cohen's d: -1.57, 95% CI: -3.39 to 0.26), I2: 96.02%, 69 severe malaria cases/256 nonsevere malaria cases). Innovation and Conclusion: The blood levels of SOD were lower in malaria patients compared with those without malaria infection. Further studies will be required to determine the extent to which SOD might prevent Plasmodium infections during pregnancy. Antioxid. Redox Signal. 40, 222-235.