Role of Perampanel in the Management of Pediatric Epilepsies in Asia: Expert Opinion
Issued Date
2024-02-01
Resource Type
ISSN
08878994
eISSN
18735150
Scopus ID
2-s2.0-85178590862
Pubmed ID
38041905
Journal Title
Pediatric Neurology
Volume
151
Start Page
5
End Page
16
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pediatric Neurology Vol.151 (2024) , 5-16
Suggested Citation
Lee W.T. Role of Perampanel in the Management of Pediatric Epilepsies in Asia: Expert Opinion. Pediatric Neurology Vol.151 (2024) , 5-16. 16. doi:10.1016/j.pediatrneurol.2023.09.023 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91467
Title
Role of Perampanel in the Management of Pediatric Epilepsies in Asia: Expert Opinion
Author(s)
Author's Affiliation
Siriraj Hospital
Children’s Hospital of Fudan University
Seoul National University Children's Hospital
National Taiwan University Hospital
University of the Philippines Manila
KK Women's And Children's Hospital
All India Institute of Medical Sciences, New Delhi
Aichi Medical University
Pamela Youde Nethersole Eastern Hospital
Children’s Hospital of Fudan University
Seoul National University Children's Hospital
National Taiwan University Hospital
University of the Philippines Manila
KK Women's And Children's Hospital
All India Institute of Medical Sciences, New Delhi
Aichi Medical University
Pamela Youde Nethersole Eastern Hospital
Other Contributor(s)
Abstract
Management of pediatric epilepsies poses unique challenges around diagnosis, treatment options, comorbidities, and the potential for these factors to interact with processes in the developing brain. In pediatric patients, broad-spectrum antiseizure medications (ASMs) with minimal potential for adverse events (AEs) and limited impact on cognition and behavior are preferred. Perampanel is a first-in-class ASM with broad-spectrum efficacy, a tolerable safety profile, minimal negative impact on cognitive function, and other features that make it a viable treatment option in this patient population. However, evidence and experience of its use in pediatric patients are less extensive than in adult patients. Experts in pediatric epilepsy across the region convened at a series of meetings to discuss the use of perampanel in pediatric patients, including dose optimization, AE prevention and management, and considerations in particular groups. This article summarizes key evidence for perampanel in the pediatric population and consolidates the experts’ recommendations for using the ASM in managing pediatric epilepsies.