Prevalence of Incidental Normocephalic Craniosynostosis: Findings From a Large Cohort Study
Issued Date
2025-01-01
Resource Type
ISSN
10492275
eISSN
15363732
Scopus ID
2-s2.0-105004313065
Journal Title
Journal of Craniofacial Surgery
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SCOPUS
Bibliographic Citation
Journal of Craniofacial Surgery (2025)
Suggested Citation
Matwatthanakit K., Poungjantaradej N., Charernsook S., Ngamsombat C., Chaisrisawadisuk S. Prevalence of Incidental Normocephalic Craniosynostosis: Findings From a Large Cohort Study. Journal of Craniofacial Surgery (2025). doi:10.1097/SCS.0000000000011445 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/110078
Title
Prevalence of Incidental Normocephalic Craniosynostosis: Findings From a Large Cohort Study
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Abstract
Craniosynostosis involves premature fusion of cranial sutures, potentially causing craniofacial deformities and increased intracranial pressure. However, emerging evidence of normocephalic sagittal craniosynostosis challenges traditional surgical management paradigms. In a retrospective cross-sectional study (2012-2022) at Siriraj Hospital, a tertiary referral centre in Thailand, the authors examined cranial computed tomography scans of 1364 patients aged 1 to 20 years. Three-dimensional imaging analyses were used to assess suture fusion, and demographic and clinical data were collected. Statistical methods were used to evaluate the prevalence and ensure reliability of the findings. Complete fusion was rare: coronal (1/1364; 0.007%), sagittal (19/1364; 1.39%), lambdoid (2/1364; 0.15%), and squamosal (24/1364; 1.76%). Partial fusion occurred in the sagittal (39/1364; 2.86%), squamosal (42/1364; 3.08%), coronal (22/1364; 1.61%), and lambdoid (22/1364; 1.61%) sutures. Notably, these patients exhibited normocephalic morphology, suggesting that certain instances of early suture fusion may represent normal anatomical variants rather than pathologic synostosis. Normocephalic craniosynostosis involving coronal, sagittal, lambdoid, and squamosal sutures was detected within this contemporary Thai cohort. These findings underscore the need for meticulous clinical assessments to distinguish benign variants from true pathologic conditions, thereby informing more nuanced, individualised treatment strategies.