Direct Immunofluorescence in Cutaneous and Systemic Lupus Erythematosus: A Literature Review
Issued Date
2023-01-01
Resource Type
eISSN
22288082
Scopus ID
2-s2.0-85150795504
Journal Title
Siriraj Medical Journal
Volume
75
Issue
2
Start Page
145
End Page
166
Rights Holder(s)
SCOPUS
Bibliographic Citation
Siriraj Medical Journal Vol.75 No.2 (2023) , 145-166
Suggested Citation
Rujitharanawong C., Kulthanan K., Tuchinda P., Pinkaew S., Chanchaemsri N., Nuttawong S., Chularojanamontri L. Direct Immunofluorescence in Cutaneous and Systemic Lupus Erythematosus: A Literature Review. Siriraj Medical Journal Vol.75 No.2 (2023) , 145-166. 166. doi:10.33192/smj.v75i2.260754 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82547
Title
Direct Immunofluorescence in Cutaneous and Systemic Lupus Erythematosus: A Literature Review
Author's Affiliation
Other Contributor(s)
Abstract
Cutaneous manifestations of lupus erythematosus (LE) have a variety of clinical phenotypes and require proper investigation for diagnosis. Knowledge of the direct immunofluorescence (DIF) technique has improved and played an important role in the diagnosis of cutaneous LE. This review explores and summarizes reported DIF findings of each cutaneous LE variant. Historically, DIF findings of cutaneous LE have revealed deposits of multiple immunoreactants at the dermo-epidermal junction with either linear or granular patterns. Immunoglobulin M is the most common immunoreactant and DIF findings of cutaneous LE variants overlap. Therefore, diagnosis of cutaneous LE requires a combination of monitoring patient history, physical examinations and laboratory studies. This review helps interpret and better understand the application of DIF studies in cutaneous LE