Increased bisphenol A levels in Thai children and adolescents with type 1 diabetes mellitus
Issued Date
2022-01-01
Resource Type
ISSN
13288067
eISSN
1442200X
Scopus ID
2-s2.0-85124878279
Pubmed ID
34342913
Journal Title
Pediatrics International
Volume
64
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pediatrics International Vol.64 No.1 (2022)
Suggested Citation
Tosirisuk N. Increased bisphenol A levels in Thai children and adolescents with type 1 diabetes mellitus. Pediatrics International Vol.64 No.1 (2022). doi:10.1111/ped.14944 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/86665
Title
Increased bisphenol A levels in Thai children and adolescents with type 1 diabetes mellitus
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Background: The incidence of type 1 diabetes mellitus (T1DM) in children and adolescents continues to increase worldwide. The reason for this is unclear. In addition to the role of genetics, bisphenol A (BPA) has been investigated as a possible causal factor for T1DM. This study aimed to determine the correlation between urinary BPA levels and T1DM in Thai children and adolescents. Methods: A cross-sectional study was conducted in T1DM patients who were followed at the endocrinology clinic at King Chulalongkorn Memorial Hospital from December 2018 to December 2019 and age-matched healthy controls. Urinary BPA levels were analyzed by high-performance liquid chromatography and adjusted by urine creatinine. Anthropometric data were measured in all participants and clinical data were collected for the T1DM patients. All participants completed a questionnaire regarding possible BPA exposures. Multivariate logistic regression analysis was used to estimate the adjusted odds ratio for T1DM. Results: Seventy-five T1DM patients and 113 age-matched controls were included in the study. The mean age for T1DM and control groups were 14.8 ± 5.7 and 14.4 ± 6.2 years, respectively. The T1DM group had a significantly higher median (interquartile range) level of adjusted urinary BPA compared to the control (31.50 [7.87, 69.45] vs 10.1 [0, 54.01] μg/g creatinine, P = 0.02). Urinary BPA of 17 μg/g creatinine or more was significantly associated with TIDM, with adjusted odds ratio (95% Confident interval, CI) of 2.38 (1.27, 4.44), P = 0.006. Conclusions: Higher urinary BPA level is one of the possible risk factors for T1DM.