Long-term multiple metabolic abnormalities among healthy and high-risk people following nonsevere COVID-19
Issued Date
2023-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85169404299
Pubmed ID
37653091
Journal Title
Scientific Reports
Volume
13
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.13 No.1 (2023)
Suggested Citation
Washirasaksiri C., Sayabovorn N., Ariyakunaphan P., Kositamongkol C., Chaisathaphol T., Sitasuwan T., Tinmanee R., Auesomwang C., Nimitpunya P., Woradetsittichai D., Chayakulkeeree M., Phoompoung P., Mayurasakorn K., Sookrung N., Tungtrongchitr A., Wanitphakdeedecha R., Muangman S., Senawong S., Tangjittipokin W., Sanpawitayakul G., Nopmaneejumruslers C., Vamvanij V., Phisalprapa P., Srivanichakorn W. Long-term multiple metabolic abnormalities among healthy and high-risk people following nonsevere COVID-19. Scientific Reports Vol.13 No.1 (2023). doi:10.1038/s41598-023-41523-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/89620
Title
Long-term multiple metabolic abnormalities among healthy and high-risk people following nonsevere COVID-19
Author(s)
Washirasaksiri C.
Sayabovorn N.
Ariyakunaphan P.
Kositamongkol C.
Chaisathaphol T.
Sitasuwan T.
Tinmanee R.
Auesomwang C.
Nimitpunya P.
Woradetsittichai D.
Chayakulkeeree M.
Phoompoung P.
Mayurasakorn K.
Sookrung N.
Tungtrongchitr A.
Wanitphakdeedecha R.
Muangman S.
Senawong S.
Tangjittipokin W.
Sanpawitayakul G.
Nopmaneejumruslers C.
Vamvanij V.
Phisalprapa P.
Srivanichakorn W.
Sayabovorn N.
Ariyakunaphan P.
Kositamongkol C.
Chaisathaphol T.
Sitasuwan T.
Tinmanee R.
Auesomwang C.
Nimitpunya P.
Woradetsittichai D.
Chayakulkeeree M.
Phoompoung P.
Mayurasakorn K.
Sookrung N.
Tungtrongchitr A.
Wanitphakdeedecha R.
Muangman S.
Senawong S.
Tangjittipokin W.
Sanpawitayakul G.
Nopmaneejumruslers C.
Vamvanij V.
Phisalprapa P.
Srivanichakorn W.
Author's Affiliation
Other Contributor(s)
Abstract
Few studies have identified the metabolic consequences of the post-acute phase of nonsevere COVID-19. This prospective study examined metabolic outcomes and associated factors in nonsevere, RT-PCR-confirmed COVID-19. The participants’ metabolic parameters, the prevalence of long-term multiple metabolic abnormalities (≥ 2 components), and factors influencing the prevalence were assessed at 1, 3, and 6 months post-onset. Six hundred individuals (mean age 45.5 ± 14.5 years, 61.7% female, 38% high-risk individuals) with nonsevere COVID-19 attended at least one follow-up visit. The prevalence of worsening metabolic abnormalities was 26.0% for BMI, 43.2% for glucose, 40.5% for LDL-c, 19.1% for liver, and 14.8% for C-reactive protein. Except for lipids, metabolic-component abnormalities were more prevalent in high-risk hosts than in healthy individuals. The prevalence of multiple metabolic abnormalities at the 6-month follow-up was 41.3% and significantly higher in high-risk than healthy hosts (49.2% vs 36.5%; P = 0.007). Factors independently associated with a lower risk of these abnormalities were being female, having dyslipidemia, and receiving at least 3 doses of the COVID-19 vaccine. These findings suggest that multiple metabolic abnormalities are the long-term consequences of COVID-19. For both high-risk and healthy individuals with nonsevere COVID-19, healthcare providers should monitor metabolic profiles, encourage healthy behaviors, and ensure complete vaccination.