Genomic Sequencing Profiles of Mycobacterium tuberculosis in Mandalay Region, Myanmar
Issued Date
2023-04-01
Resource Type
eISSN
24146366
Scopus ID
2-s2.0-85153740555
Journal Title
Tropical Medicine and Infectious Disease
Volume
8
Issue
4
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tropical Medicine and Infectious Disease Vol.8 No.4 (2023)
Suggested Citation
Phyu A.N., Aung S.T., Palittapongarnpim P., Htet K.K.K., Mahasirimongkol S., Ruangchai W., Jaemsai B., Aung H.L., Maung H.M.W., Chaiprasert A., Pungrassami P., Chongsuvivatwong V. Genomic Sequencing Profiles of Mycobacterium tuberculosis in Mandalay Region, Myanmar. Tropical Medicine and Infectious Disease Vol.8 No.4 (2023). doi:10.3390/tropicalmed8040239 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81927
Title
Genomic Sequencing Profiles of Mycobacterium tuberculosis in Mandalay Region, Myanmar
Other Contributor(s)
Abstract
This study aimed to characterize whole-genome sequencing (WGS) information of Mycobacterium tuberculosis (Mtb) in the Mandalay region of Myanmar. It was a cross-sectional study conducted with 151 Mtb isolates obtained from the fourth nationwide anti-tuberculosis (TB) drug-resistance survey. Frequency of lineages 1, 2, 3, and 4 were 55, 65, 9, and 22, respectively. The most common sublineage was L1.1.3.1 (n = 31). Respective multi-drug resistant tuberculosis (MDR-TB) frequencies were 1, 1, 0, and 0. Four clusters of 3 (L2), 2 (L4), 2 (L1), and 2 (L2) isolates defined by a 20-single-nucleotide variant (SNV) cutoff were detected. Simpson’s index for sublineages was 0.0709. Such high diversity suggests that the area probably had imported Mtb from many geographical sources. Relatively few genetic clusters and MDR-TB suggest there is a chance the future control will succeed if it is carried out properly.