Risk factors for systemic reactions in typical cold urticaria: Results from the COLD-CE study
Issued Date
2022-07-01
Resource Type
ISSN
01054538
eISSN
13989995
Scopus ID
2-s2.0-85121601539
Pubmed ID
34862605
Journal Title
Allergy: European Journal of Allergy and Clinical Immunology
Volume
77
Issue
7
Start Page
2185
End Page
2199
Rights Holder(s)
SCOPUS
Bibliographic Citation
Allergy: European Journal of Allergy and Clinical Immunology Vol.77 No.7 (2022) , 2185-2199
Suggested Citation
Bizjak M., Košnik M., Dinevski D., Thomsen S.F., Fomina D., Borzova E., Kulthanan K., Meshkova R., Ahsan D.M., Al-Ahmad M., Altrichter S., Bauer A., Brockstädt M., Costa C., Demir S., Fachini Criado R., Ensina L.F., Gelincik A., Giménez-Arnau A.M., Gonçalo M., Gotua M., Holm J.G., Inomata N., Kasperska-Zajac A., Khoshkhui M., Klyucharova A., Kocatürk E., Lu R., Makris M., Maltseva N., Miljković J., Pasali M., Paulino M., Pesqué D., Peter J., Ramón G.D., Ritchie C., Rodrigues Valle S.O., Rudenko M., Sikora A., de Souza Lima E.M., Wagner N., Xepapadaki P., Xue X., Zhao Z., Terhorst-Molawi D., Maurer M. Risk factors for systemic reactions in typical cold urticaria: Results from the COLD-CE study. Allergy: European Journal of Allergy and Clinical Immunology Vol.77 No.7 (2022) , 2185-2199. 2199. doi:10.1111/all.15194 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84966
Title
Risk factors for systemic reactions in typical cold urticaria: Results from the COLD-CE study
Author(s)
Bizjak M.
Košnik M.
Dinevski D.
Thomsen S.F.
Fomina D.
Borzova E.
Kulthanan K.
Meshkova R.
Ahsan D.M.
Al-Ahmad M.
Altrichter S.
Bauer A.
Brockstädt M.
Costa C.
Demir S.
Fachini Criado R.
Ensina L.F.
Gelincik A.
Giménez-Arnau A.M.
Gonçalo M.
Gotua M.
Holm J.G.
Inomata N.
Kasperska-Zajac A.
Khoshkhui M.
Klyucharova A.
Kocatürk E.
Lu R.
Makris M.
Maltseva N.
Miljković J.
Pasali M.
Paulino M.
Pesqué D.
Peter J.
Ramón G.D.
Ritchie C.
Rodrigues Valle S.O.
Rudenko M.
Sikora A.
de Souza Lima E.M.
Wagner N.
Xepapadaki P.
Xue X.
Zhao Z.
Terhorst-Molawi D.
Maurer M.
Košnik M.
Dinevski D.
Thomsen S.F.
Fomina D.
Borzova E.
Kulthanan K.
Meshkova R.
Ahsan D.M.
Al-Ahmad M.
Altrichter S.
Bauer A.
Brockstädt M.
Costa C.
Demir S.
Fachini Criado R.
Ensina L.F.
Gelincik A.
Giménez-Arnau A.M.
Gonçalo M.
Gotua M.
Holm J.G.
Inomata N.
Kasperska-Zajac A.
Khoshkhui M.
Klyucharova A.
Kocatürk E.
Lu R.
Makris M.
Maltseva N.
Miljković J.
Pasali M.
Paulino M.
Pesqué D.
Peter J.
Ramón G.D.
Ritchie C.
Rodrigues Valle S.O.
Rudenko M.
Sikora A.
de Souza Lima E.M.
Wagner N.
Xepapadaki P.
Xue X.
Zhao Z.
Terhorst-Molawi D.
Maurer M.
Author's Affiliation
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Universitätsklinikum Carl Gustav Carus Dresden
Siriraj Hospital
Medicinska Fakulteta Univerze v Mariboru
Graduate School of Medicine
Kepler Universitätsklinikum
The Third Affiliated Hospital, Sun Yat-sen University
Peking University First Hospital
University of Cape Town Lung Institute
Bolnišnica Golnik
Pirogov Russian National Research Medical University (RNRMU)
Kazan Federal University
Kazan State Medical University
Kuwait University
Universidade de Coimbra, Faculdade de Medicina
Københavns Universitet
Universitätsklinikum Erlangen
National and Kapodistrian University of Athens
Charité – Universitätsmedizin Berlin
Universitat Autònoma de Barcelona
Univerza v Ljubljani Medicinska Fakulteta
Santa Maria Hospital, Lisbon
Centro Universitário FMABC
Universidade Federal de São Paulo
İstanbul Tıp Fakültesi
Sechenov First Moscow State Medical University
Instituto Universitario del Hospital Italiano de Buenos Aires
Koç Üniversitesi
Smolensk State Medical Academy
Mashhad University of Medical Sciences
University of Cape Town
Universidade Federal do Rio de Janeiro
Urticaria Center of Reference and Excellence (UCARE)
Dermatology and Allergology of Medical University of Silesia
Clinical State Hospital 52
Community Health Centre
London Allergy and Immunology Centre
Hospital Maternidade Therezinha de Jesus
Instituto de Alergia e Inmunologia del Sur
Universitätsklinikum Carl Gustav Carus Dresden
Siriraj Hospital
Medicinska Fakulteta Univerze v Mariboru
Graduate School of Medicine
Kepler Universitätsklinikum
The Third Affiliated Hospital, Sun Yat-sen University
Peking University First Hospital
University of Cape Town Lung Institute
Bolnišnica Golnik
Pirogov Russian National Research Medical University (RNRMU)
Kazan Federal University
Kazan State Medical University
Kuwait University
Universidade de Coimbra, Faculdade de Medicina
Københavns Universitet
Universitätsklinikum Erlangen
National and Kapodistrian University of Athens
Charité – Universitätsmedizin Berlin
Universitat Autònoma de Barcelona
Univerza v Ljubljani Medicinska Fakulteta
Santa Maria Hospital, Lisbon
Centro Universitário FMABC
Universidade Federal de São Paulo
İstanbul Tıp Fakültesi
Sechenov First Moscow State Medical University
Instituto Universitario del Hospital Italiano de Buenos Aires
Koç Üniversitesi
Smolensk State Medical Academy
Mashhad University of Medical Sciences
University of Cape Town
Universidade Federal do Rio de Janeiro
Urticaria Center of Reference and Excellence (UCARE)
Dermatology and Allergology of Medical University of Silesia
Clinical State Hospital 52
Community Health Centre
London Allergy and Immunology Centre
Hospital Maternidade Therezinha de Jesus
Instituto de Alergia e Inmunologia del Sur
Other Contributor(s)
Abstract
Background: Cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods: An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results: Of 551 ColdU patients, 75% (n = 412) had a positive CST and ColdA occurred in 37% (n = 151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n = 40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs. 39%, p =.003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion: ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector.