In Vitro Tracking of Sporozoites via Fluorescence Imaging and MRI Using Multifunctional Micelles
Issued Date
2023-12-18
Resource Type
eISSN
25766422
Scopus ID
2-s2.0-85179811415
Pubmed ID
38039355
Journal Title
ACS Applied Bio Materials
Volume
6
Issue
12
Start Page
5324
End Page
5332
Rights Holder(s)
SCOPUS
Bibliographic Citation
ACS Applied Bio Materials Vol.6 No.12 (2023) , 5324-5332
Suggested Citation
Assawapanumat W., Roobsoong W., Chotivanich K., Sattabongkot J., Kampaengtip A., Sungkarat W., Sunintaboon P., Nasongkla N. In Vitro Tracking of Sporozoites via Fluorescence Imaging and MRI Using Multifunctional Micelles. ACS Applied Bio Materials Vol.6 No.12 (2023) , 5324-5332. 5332. doi:10.1021/acsabm.3c00596 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/95668
Title
In Vitro Tracking of Sporozoites via Fluorescence Imaging and MRI Using Multifunctional Micelles
Corresponding Author(s)
Other Contributor(s)
Abstract
Early detection could increase the treatment efficiency and prevent the recurrence of malaria disease. To track and detect malarial sporozoites, novel drug delivery systems have been explored for their ability to target these parasites specifically. This study investigates the potential of micelles to track Plasmodium vivax by targeting the Plasmodium vivax hexose transporter using glucose-based interactions. In vitro experiments were conducted using glucose/SPIO/Nile red (targeted) micelles and methoxy/SPIO/Nile red (nontargeted) micelles, revealing that the targeted micelles exhibited stronger fluorescence with the sporozoites and higher relative R2* values compared to the nontargeted micelles. These findings suggest that targeted micelles could be used for the specific detection of Plasmodium sporozoites using fluorescence imaging and MRI techniques, offering a promising approach for efficient malaria parasite detection.