Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis
1
Issued Date
2022-06-01
Resource Type
ISSN
03008126
eISSN
14390973
Scopus ID
2-s2.0-85122288369
Pubmed ID
34985688
Journal Title
Infection
Volume
50
Issue
3
Start Page
725
End Page
737
Rights Holder(s)
SCOPUS
Bibliographic Citation
Infection Vol.50 No.3 (2022) , 725-737
Suggested Citation
Charoenngam N., Ponvilawan B., Thongpiya J., Yingchoncharoen P., Chaikijurajai T., Chaisidhivej N., Apovian C.M., Ungprasert P. Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis. Infection Vol.50 No.3 (2022) , 725-737. 737. doi:10.1007/s15010-021-01749-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85855
Title
Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis
Other Contributor(s)
Abstract
Objective: To comprehensively investigate the association between obesity/high body mass index (BMI) and risk of Clostridioides difficile infection (CDI) using systematic review and meta-analysis. Methods: Potentially eligible studies were identified from Medline and EMBASE databases from inception to February 2021 using search strategy consisting of terms for “Body Mass Index” and “Clostridioides Difficile”. We only included studies that consist of a group of individuals with CDI and another group without CDI. Then, the studies must report their BMI or history of obesity. Odds ratio (OR) and 95% CIs of the association between BMI status and CDI were retrieved from each study and combined using the generic inverse variance method. Funnel plot was used to assess publication bias. Results: A total of 4609 articles were identified. After two rounds of systematic review, 17 studies met the eligibility criteria and were included into the meta-analysis. Pooled analysis showed that individuals with high BMI had a significantly decreased odds of CDI with the pooled OR of 0.88 (95% CI 0.80–0.97). This meta-analysis had high statistical heterogeneity with I2 of 74%. Funnel plot was symmetric, which was not suggestive of presence of publication bias. Conclusion: This meta-analysis revealed a significant negative association between BMI and CDI.