Bed Rest versus Tocolytic Therapy in Threatened Preterm Labour Stratified by Cervical Length: A Randomised Controlled Trial
Issued Date
2026-01-01
Resource Type
eISSN
11791411
Scopus ID
2-s2.0-105032415135
Journal Title
International Journal of Women S Health
Volume
18
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Women S Health Vol.18 (2026)
Suggested Citation
Chawanpaiboon S., Pooliam J. Bed Rest versus Tocolytic Therapy in Threatened Preterm Labour Stratified by Cervical Length: A Randomised Controlled Trial. International Journal of Women S Health Vol.18 (2026). doi:10.2147/IJWH.S576580 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115747
Title
Bed Rest versus Tocolytic Therapy in Threatened Preterm Labour Stratified by Cervical Length: A Randomised Controlled Trial
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Author's Affiliation
Corresponding Author(s)
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Abstract
Aim: Management of threatened preterm labour (TPL) frequently involves tocolytic drug administration, which may lead to unnecessary interventions and maternal complications, especially in women at low risk of imminent preterm birth. Cervical length measurement is a reliable method for assessing preterm birth risk and guiding appropriate management. However, tocolytic drugs and antenatal corticosteroids are often overused in women with adequate cervical length. Methods: This randomised controlled trial compared the effectiveness of bed rest versus tocolytic therapy in women with threatened preterm labour and a cervical length ≥ 20 mm. Participants were allocated to either bed rest or tocolytic treatment. Primary outcomes included preterm delivery rates and birth weight. Secondary outcomes were caesarean section rates, antenatal corticosteroid use, maternal complications, and healthcare costs. Results: Women receiving tocolytic therapy had a significantly higher rate of antenatal corticosteroid use (79%, p < 0.0001) and increased caesarean section rates compared with those managed with bed rest. Birth weight was higher among the bed rest group. No differences were found in preterm delivery rates or maternal complications between groups. Conclusion: Bed rest alone is sufficient for managing threatened preterm labour in women with a cervical length ≥ 20 mm. The use of tocolytic drugs in this low-risk population may result in unnecessary interventions, higher caesarean rates, and increased healthcare costs. Bed rest is a safe, effective, and cost-efficient alternative to pharmacologic therapy in preventing preterm delivery while minimising maternal complications. Trial Registration Page: https://www.thaiclinicaltrials.org/show/TCTR20200617001: 17/06/2020.