Extranodal natural killer/T-cell lymphoma presenting as hypopyon panuveitis: a case report
Issued Date
2022-12-01
Resource Type
eISSN
14712415
Scopus ID
2-s2.0-85124020408
Pubmed ID
35100995
Journal Title
BMC Ophthalmology
Volume
22
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
BMC Ophthalmology Vol.22 No.1 (2022)
Suggested Citation
Sukon N., Tesavibul N., Choopong P., Panyayingyong N., Boonsopon S. Extranodal natural killer/T-cell lymphoma presenting as hypopyon panuveitis: a case report. BMC Ophthalmology Vol.22 No.1 (2022). doi:10.1186/s12886-022-02277-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85351
Title
Extranodal natural killer/T-cell lymphoma presenting as hypopyon panuveitis: a case report
Author's Affiliation
Other Contributor(s)
Abstract
Background: Extranodal natural killer/T-cell lymphoma (ENKTL), nasal type, generally affects the orbit by direct extension. It can even rarely present as severe intraocular inflammation mimicking endophthalmitis. Delayed diagnosis and treatment are frequently reported. Case presentation: A 43-year-old woman presented with 2-month blurred vision in her left eye. Ocular examination revealed hypopyon panuveitis. She was initially diagnosed with endogenous endophthalmitis, which proved irresponsive to antimicrobial therapy. High-dose prednisolone was given afterward, but this failed to stop the development and continuous progression of ocular inflammation. The diagnosis of ENKTL was finally confirmed from the pathological findings of oral ulcers and cervical lymph nodes and chemotherapy was prescribed. After the first cycle of chemotherapy, the patient’s ocular inflammation subsided. Unfortunately, her left eye became phthisis with progressive visual loss within 9 months following the diagnosis. Conclusions: The diagnosis of intraocular ENKTL is frequently delayed, which can lead to severe problems for treatment as the disease is aggressive with a poor prognosis. It can be found not only in elderly patients but also in a middle-aged individual. In patients with ocular inflammation, a thorough systemic evaluation and histopathological examination of the associated systemic findings is extremely helpful and may reveal the cause of the ocular inflammation, including revealing possible ENKTL.