The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients
Issued Date
2023-06-01
Resource Type
eISSN
2476762X
Scopus ID
2-s2.0-85163617666
Pubmed ID
37378936
Journal Title
Asian Pacific journal of cancer prevention : APJCP
Volume
24
Issue
6
Start Page
2055
End Page
2059
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific journal of cancer prevention : APJCP Vol.24 No.6 (2023) , 2055-2059
Suggested Citation
Sanguansin S., Saelee P., Kritsirivuttinan K., Pongstaporn W. The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients. Asian Pacific journal of cancer prevention : APJCP Vol.24 No.6 (2023) , 2055-2059. 2059. doi:10.31557/APJCP.2023.24.6.2055 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87951
Title
The Association of pre-miR27a Gene Polymorphism and Clinicopathological Data in Thai Breast Cancer Patients
Author's Affiliation
Other Contributor(s)
Abstract
BACKGROUND: MiR27a plays an important role in carcinogenesis, cell proliferation, apoptosis, invasion, migration and angiogenesis. Several studies have identified an important role of pre-miR27a (rs895819) A>G polymorphism in several types of cancer. This research aims to investigate the association of pre-miR27a (rs895819) A>G and breast cancer susceptibility, clinicopathological data and survival. Blood DNA samples of 143 Thai breast cancer patients and 100 healthy Thai women were studied for pre-miR27a (rs895819) A>G polymorphism using polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP). RESULTS: The results revealed that the frequency of pre-miR27a (rs895819) A>G genotypes was not statistically significant different between breast cancer patient and normal control subjects. The rs895819 A>G genotype was significantly associated with clinicopathological parameter of grade III differentiation (P = 0.006), progesterone receptor (P = 0.011) and triple negative (P = 0.031) in breast cancer patients, but not with breast cancer susceptibility. CONCLUSION: The pre-miR27a (rs895819) A>G genotype was significantly associated with poorly differentiated, progesterone receptor and triple-negative in breast cancer patients. Therefore, pre-miR27a (rs895819) A>G may be used as a biomarker for poor prognosis.