Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer
Issued Date
2022-04-01
Resource Type
ISSN
01435221
eISSN
14708736
Scopus ID
2-s2.0-85128793332
Pubmed ID
35445707
Journal Title
Clinical Science
Volume
136
Issue
8
Start Page
521
End Page
535
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Science Vol.136 No.8 (2022) , 521-535
Suggested Citation
Hatthakarnkul P., Quinn J.A., Ammar A., Lynch G., Van Wyk H., McMillan D.C., Thuwajit C., Edwards J. Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer. Clinical Science Vol.136 No.8 (2022) , 521-535. 535. doi:10.1042/CS20210886 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85975
Title
Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer
Author's Affiliation
Other Contributor(s)
Abstract
Colorectal cancer (CRC) is the third most common cancer worldwide. Poor survival of CRC associated with the development of tumour metastasis led to the investigation of the potential biomarkers to predict outcomes in CRC patients. Tumour budding (TB) is a well-known independent prognostic marker for poor survival and disease metastasis. Therefore, it has been suggested that TB status is included in routine clinicopathological factors for risk assessment in CRC. In contrast with a vast majority of studies regarding the prognostic power of TB, there is no clear evidence pertaining to the underlying molecular mechanism driving this phenotype, or an understanding of TB relationship with the tumour microenvironment (TME). The aim of the present study is to present a comprehensive review of TB and tumour cell signalling pathways together with the cross-talk of immune cells that could drive TB formation in CRC.
