Increased Salivary Periodontal Pathogens and IL-17A in Oral Lichen Planus Patients with or without Periodontitis
3
Issued Date
2022-05-01
Resource Type
ISSN
09766006
eISSN
09766014
Scopus ID
2-s2.0-85128810076
Journal Title
World Journal of Dentistry
Volume
13
Issue
3
Start Page
182
End Page
190
Rights Holder(s)
SCOPUS
Bibliographic Citation
World Journal of Dentistry Vol.13 No.3 (2022) , 182-190
Suggested Citation
Talungchit S., Buajeeb W., Khovidhunkit S.O.P., Surarit R., Chairatvit K., Roytrakul S., Kobayashi H., Izumi Y. Increased Salivary Periodontal Pathogens and IL-17A in Oral Lichen Planus Patients with or without Periodontitis. World Journal of Dentistry Vol.13 No.3 (2022) , 182-190. 190. doi:10.5005/jp-journals-10015-2049 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84448
Title
Increased Salivary Periodontal Pathogens and IL-17A in Oral Lichen Planus Patients with or without Periodontitis
Other Contributor(s)
Abstract
Aim: Patients with oral lichen planus (OLP) who have gingival involvement are at increased risk for periodontal disease. This study aimed to investigate salivary levels of periodontopathic bacteria and inflammatory cytokines in OLP patients with or without periodontitis. Materials and methods: Seventeen OLP patients and 20 control subjects were evaluated for their Periodontal Screening and Recording (PSR) score to classify if they had periodontitis. Four groups were studied, OLP patients with periodontitis (OLP-P), without periodontitis (OLP), periodontitis patients (P) and normal subjects (N). Salivary levels of Aggregatibacter actinomycetemcomitans (Aa), Fusobacterium nucleatum (Fn), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Treponema denticola (Td), and Tannerella forsythia (Tf) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Salivary levels of interleukin (IL)-1β, IL-6, and IL-17A were measured by enzyme-linked immunosorbent assay (ELISA). Results: OLP-P and P groups had higher plaque index, bleeding on probing, and PSR scores than other groups. OLP-P and OLP patients had increased salivary Aa, Fn, Pi, Td, Tf with significantly high levels of Pi as well as high salivary IL-1β, IL-6, and IL-17A. IL-17A levels were significantly highest in the OLP-P group. Salivary IL-1β was significantly correlated with the level of Pi. Conclusion: OLP patients with or without periodontitis had high levels of salivary periodontal pathogens and IL-17A. Clinical significance: These data supported that OLP patients were at high risk for periodontitis. Oral hygiene maintenance in OLP patients with gingival lesions is of importance and could help prevent periodontitis.