Clinical Presentations of Early-Onset Schizophrenia: A 10-Year Retrospective Chart Review
4
Issued Date
2023-02-01
Resource Type
ISSN
01252208
Scopus ID
2-s2.0-85148996137
Journal Title
Journal of the Medical Association of Thailand
Volume
106
Issue
2
Start Page
172
End Page
179
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand Vol.106 No.2 (2023) , 172-179
Suggested Citation
Poovichayasumlit C., Limsuwan N. Clinical Presentations of Early-Onset Schizophrenia: A 10-Year Retrospective Chart Review. Journal of the Medical Association of Thailand Vol.106 No.2 (2023) , 172-179. 179. doi:10.35755/jmedassocthai.2023.02.13779 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82683
Title
Clinical Presentations of Early-Onset Schizophrenia: A 10-Year Retrospective Chart Review
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Objective: To collect and describe the clinical presentations of early-onset schizophrenia in a clinical setting. In addition, the authors aimed to compare the clinical presentations of early-onset schizophrenia (EOS) and very early-onset schizophrenia (VEOS). Materials and Methods: A 10-year retrospective chart review of early-onset schizophrenia participants, both inpatients and outpatients, who received psychiatric treatments at Ramathibodi Hospital, Bangkok, Thailand between January 2011 and December 2020. Subjects were divided into two groups by age of onset symptoms, 1) EOS with onset between 13- to 18-years-old, and 2) VEOS with onset before 13-years-old. Descriptive statistics in term of frequency and percentage were used to describe clinical characteristics. Regarding the comparisons between groups, the differences were considered as statistically significant at the level of a p-value of less than 0.05. Results: Forty-one participants were analyzed. The VEOS subgroup included nine participants (22%) and EOS subgroup included 32 participants (78%). The age of symptom onset ranged from 7.9 to 17.7 years old, with a mean of 14.2 years old (SD 2.5 years). The diagnostic stability was 82.9%. Thirty-seven (90.2%) and 39 participants (95.1%) demonstrated delusion and auditory hallucination, respectively. Only 13 participants (31.7%) reported visual hallucination. Moreover, there were statistically significant differences between EOS and VEOS on gender, other psychiatric comorbidities apart from depressive disorders, and the number of other psychotropic medication classes apart from antipsychotic medications. The female predominance demonstrated in VEOS subgroup, while the male predominance was found in EOS subgroup. Conclusion: Although EOS was rare, the diagnostic stability of EOS was high. Auditory hallucination was the most common psychotic presentation reported in this population. The female predominance was demonstrated in the VEOS subgroup, while the male predominance was found in the EOS subgroup.