Pneumococcal colonization and severity of pneumonia in hospitalized Cambodian children following introduction of the 13-valent pneumococcal conjugate vaccine
4
Issued Date
2023-09-01
Resource Type
eISSN
27727076
Scopus ID
2-s2.0-85161543148
Journal Title
IJID Regions
Volume
8
Start Page
9
End Page
15
Rights Holder(s)
SCOPUS
Bibliographic Citation
IJID Regions Vol.8 (2023) , 9-15
Suggested Citation
Miliya T., Soputhy C., Leab P., Tan P., Sao S., Heffelfinger J.D., Batmunkh N., Ork V., Hossain M.S., Day N.P.J., Turner C., Turner P. Pneumococcal colonization and severity of pneumonia in hospitalized Cambodian children following introduction of the 13-valent pneumococcal conjugate vaccine. IJID Regions Vol.8 (2023) , 9-15. 15. doi:10.1016/j.ijregi.2023.05.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/87142
Title
Pneumococcal colonization and severity of pneumonia in hospitalized Cambodian children following introduction of the 13-valent pneumococcal conjugate vaccine
Other Contributor(s)
Abstract
Objectives: This study sought to characterize pneumococcal colonization and clinical/radiological features in Cambodian children admitted to hospital with an illness compatible with pneumonia following national introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods: Children aged 0–59 months admitted to Angkor Hospital for Children who met the World Health Organization (WHO) case definition for clinical pneumonia were enrolled over a 3-year period. Clinical, radiological and vaccination data were collected at enrolment. A nasopharyngeal swab was collected for detection of pneumococcal colonization using the WHO standard culture method. Results: Between 1 September 2015 and 31August 2018, 2209 analysable illness episodes were enrolled. Pneumococci were detected in 943/2209 (42.7%) children. PCV13 serotypes were detected less frequently in children who had been vaccinated appropriately for their age compared with undervaccinated children: 309/567 (53.6%) vs 216/342 (63.2%) (P=0.006). Age-appropriate PCV13 vaccination was negatively associated with hypoxic presentation [adjusted odds ratio (aOR) 0.72, 95% confidence interval (CI) 0.60–0.87; P=0.0006] and primary endpoint pneumonia on chest x ray (aOR 0.69, 95% CI 0.54–0.90; P=0.006). Conclusions: The introduction of PCV13 in Cambodia was associated with a decline in vaccine serotype nasopharyngeal colonization, and clinical and radiological severity in children hospitalized with clinical pneumonia.