Effects of thiamine and riboflavin deficencies on DDT and methyl parathion toxicities and on changes in drug metabolism induced by the pesticides
4
Issued Date
2024
Copyright Date
1992
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
x, 119 leaves
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Pharmacology))--Mahidol University, 1992
Suggested Citation
Sudaporn Chuvessiriporn Effects of thiamine and riboflavin deficencies on DDT and methyl parathion toxicities and on changes in drug metabolism induced by the pesticides. Thesis (M.Sc. (Pharmacology))--Mahidol University, 1992. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/99845
Title
Effects of thiamine and riboflavin deficencies on DDT and methyl parathion toxicities and on changes in drug metabolism induced by the pesticides
Alternative Title(s)
การศึกษาภาวะขาดวิตามินบี 1 และวิตามินบี 2 ต่อความเป็นพิษของดีดีทีและเมทธิลพาราไธออนและต่อผลของดีดีทีและเมทธิลพาราไธออนที่มีต่อการเปลี่ยนแปลงขบวนการเมตาบอลิสมของสารเคมี
Author(s)
Abstract
In many developing countries, including Thailand, deficiencies es of vitamin B especially thiamine and riboflavin is still prevalent and considered one of the- major public health problems in the poor agricultural community. Coincidentally, the population in these regions could also be exposed to various pesticides such as DDT and methyl parathion in their food and environment. Research carried out in this study is designed to investigate the effects of exposure to DDT and methyl parathion on the xenobiotic metabolic/ and detoxification systems which is beleived to be the key step in the manifestation of action and/or toxicity. Moreover, the effects of DDT and methyl parathion on the above systems during thiamine and riboflavin deficiencies were also evaluated. Xenobiotic selected for this study included: DMN, aminopyrine and aniline. Moreover, hepatic GSH content and GSH-S-transferase were also measured. DDT pretreatment for 7 days decreased the low K. of DMN demethylase I and aniline hydroxylase activities. DMN demethylase II responded differently, its activity was significantly increased after 3 and 14 days on DDT treatment. Aminopyrine demethylase and GSE-S-transferase were significantly increased after 3,7 and 14 days DDT treatment. DDT had no effect on hepatic GSH content. The effect of DDT treatment in thiamine deficient rats did not produce effect on DMN demethylase I and aniline hydroxylase,but DMN demethylase II, Aminopyrine demethylase, GSH-S-transferase and hepatic GSH content were significantly increased under this condition. The combination of DDT treatment (1 day and 3 day) and riboflvain deficiency significantly increased DMN demethylase II and aminopyrine demethylase but had no effect on GSH-S-transferase and hepatic GSR content. DHN demethylase I and aniline hydroxylase activity were decreased under this condition. The effect of methyl parathion treatment in thiamine deficient rats did not produce any effect on aniline hydroxylase, DMN demethylase I and II, GSH-S-transferase and hepatic GSH content but it decreased aminopyrine demethylase activity. The combination of methyl parathion treatment in riboflavin deficienct rat had no effect on DMN demethylase I and II, aminopyrine demethylase, aniline hydroxylase, GSH-S-transferase and hepatic GSH content. LD50 dose of DDT was slightly decreased in thiamine and riboflavin deficiency but the LD50 dose of methyl parathion was sightly increased in thiamine deficiency and it was equally toxic to control and riboflavin deficiency.
Description
Pharmacology (Mahidol University 1992)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Pharmacology
Degree Grantor(s)
Mahidol University